3-(Methoxycarbonyl)pyrazine-2-carboxylic acid

Base Information

• Chemical Name: 3-(Methoxycarbonyl)pyrazine-2-carboxylic acid
• CAS No.: 73763-86-7
• Molecular Formula: C7H6N2O4
• Molecular Weight: 182.136
• European Community (EC) Number: 873-906-4
• Mol file: 73763-86-7.mol

Synonyms:3-(methoxycarbonyl)pyrazine-2-carboxylic acid;73763-86-7;3-methoxycarbonylpyrazine-2-carboxylic acid;2,3-Pyrazinedicarboxylic acid, monomethyl ester;SCHEMBL361255;ZKBPWGREDZWROM-UHFFFAOYSA-N;AKOS006274793;VS-13576;pyrazine-2,3-dicarboxylic acid methyl ester;3-(methoxycarbonyl)pyrazine-2-carboxylicacid;E83613;EN300-252001;Z2293608377

Chemical Property of 3-(Methoxycarbonyl)pyrazine-2-carboxylic acid

Chemical Property:

• PSA: 89.38000
• LogP: -0.03860
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 182.03275668
• Heavy Atom Count: 13
• Complexity: 219

Purity/Quality:

99.90% ^*data from raw suppliers

3-(methoxycarbonyl)pyrazine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1=NC=CN=C1C(=O)O

Technology Process of 3-(Methoxycarbonyl)pyrazine-2-carboxylic acid

There total 3 articles about 3-(Methoxycarbonyl)pyrazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 2,3-pyrazinedicarboxylic anhydride (4744-50-7) → 3-[(methyloxy)carbonyl]-2-pyrazinecarboxylic acid (73763-86-7)

Guidance literature:

for 12h; Ambient temperature;

DOI:10.1080/00397919608003656

Reference yield:

2,3-dicarboxypyrazine (89-01-0) → 3-[(methyloxy)carbonyl]-2-pyrazinecarboxylic acid (73763-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / acetic anhydride / Heating

2: 100 percent / 12 h / Ambient temperature

With acetic anhydride;

DOI:10.1080/00397919608003656

Reference yield:

→ 3-[(methyloxy)carbonyl]-2-pyrazinecarboxylic acid (73763-86-7)

Guidance literature:

2,3-Pyrazin-dicarbonsaeureanhydrid, Me.;

upstream raw materials:

methanol

2,3-pyrazinedicarboxylic anhydride

2,3-dicarboxypyrazine

Downstream raw materials:

methyl pyrazine-2-carboxylate

Methyl 3-amino-2-pyrazinecarboxylate

pyrazinamide

pyrazine-2,3-dicarboxylic acid dimethyl ester

Refernces

• 1、 -. "ALDOSE REDUCTASE INHIBITORS AND USES THEREOF". Page/Page column 43; 44. . Retrieved 2012/02/02.