(1r,4r)-4-Methoxycyclohexane-1-carboxylic acid

Base Information

• Chemical Name: (1r,4r)-4-Methoxycyclohexane-1-carboxylic acid
• CAS No.: 73873-61-7
• Molecular Formula: C8H14O3
• Molecular Weight: 158.197
• Mol file: 73873-61-7.mol

Synonyms:trans-4-Methoxy-cyclohexancarbonsaeure;4-Methoxy-cyclohexanecarboxylic acid;4-methoxycyclohexanecarboxylic acid;

Chemical Property of (1r,4r)-4-Methoxycyclohexane-1-carboxylic acid

Chemical Property:

• Melting Point: 56 - 59 °C (petroleum ether)
• PSA: 46.53000
• LogP: 1.27620
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

trans-4-Methoxycyclohexanecarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: trans-4-Methoxycyclohexanecarboxylic Acid is used as a reactant in the preparation of pyrazolylmethylamino isoindoline diones as cereblon binders for degradation of Ikaros useful in treatment of diseases.

Technology Process of (1r,4r)-4-Methoxycyclohexane-1-carboxylic acid

There total 6 articles about (1r,4r)-4-Methoxycyclohexane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxybenzoic acid (100-09-4) → 4-methoxycyclohexanecarboxylic acid (73873-59-3) + trans-4-methoxycyclohexane-1-carboxylic acid (73873-61-7)

Guidance literature:

With hydrogen; In 1,4-dioxane; at 20 ℃; under 760.051 Torr; Overall yield = 27 percent; Optical yield = 72 percent de; chemoselective reaction;

DOI:10.1039/d1ob01197a

Reference yield:

methyl 4-methoxybenzoate (121-98-2) → trans-4-methoxycyclohexane-1-carboxylic acid (73873-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Raney nickel; ethanol / Hydrogenation

2: aqueous methanol. KOH

With potassium hydroxide; ethanol; nickel;

DOI:10.1021/ja01569a030

Reference yield:

Methyl cis/trans-4-methoxycyclohexanecarboxylate (137058-17-4) → 4-methoxycyclohexanecarboxylic acid (73873-59-3) + trans-4-methoxycyclohexane-1-carboxylic acid (73873-61-7)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01569a030

upstream raw materials:

Methyl cis/trans-4-methoxycyclohexanecarboxylate

methyl 4-methoxybenzoate

4-methoxybenzoic acid

Downstream raw materials:

(1r,4r)-4-methoxycyclohexane-1-carbaldehyde

((1R,4R)-4-methoxycyclohexyl)methanol

Refernces