2,2,3',4'-TETRAMETHYLPROPIOPHENONE

Base Information

• Chemical Name: 2,2,3',4'-TETRAMETHYLPROPIOPHENONE
• CAS No.: 7397-00-4
• Molecular Formula: C13H18O
• Molecular Weight: 190.28100
• Hs Code.: 2914399090
• Mol file: 7397-00-4.mol

Synonyms:4-Pivaloyl-o-xylene;2,2,2-TRIFLUOROETHYL 4-CHLOROPHENYLCARBAMATE;2,2,3',4'-TETRAMETHYLPROPIOPHENONE;

Chemical Property of 2,2,3',4'-TETRAMETHYLPROPIOPHENONE

Chemical Property:

• Vapor Pressure: 0.00325mmHg at 25°C
• Boiling Point: 283oC at 760 mmHg
• Flash Point: 115.1oC
• PSA: 17.07000
• Density: 0.936g/cm3
• LogP: 3.53220

Purity/Quality:

99% ^*data from raw suppliers

2,2,3',4'-tetramethylpropiophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,3',4'-TETRAMETHYLPROPIOPHENONE

There total 4 articles about 2,2,3',4'-TETRAMETHYLPROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-xylene (95-47-6) + pivaloyl chloride (3282-30-2) → 1-(3,4-dimethylphenyl)-2,2-dimethylpropan-1-one (7397-00-4)

Guidance literature:

With aluminium trichloride; Petroleum ether;

DOI:10.1021/jo01144a019

Reference yield:

4-bromo-o-xylene (583-71-1) + pivaloyl chloride (3282-30-2) → 1-(3,4-dimethylphenyl)-2,2-dimethylpropan-1-one (7397-00-4)

Guidance literature:

With magnesium; Multistep reaction; 1.) ether, 2.) ether, -15 deg C;

DOI:10.1246/bcsj.63.856

Reference yield:

tert-butyl isocyanide (630-18-2) + 3,4-dimethylphenylmagnesium bromide (89980-68-7) → 1-(3,4-dimethylphenyl)-2,2-dimethylpropan-1-one (7397-00-4)

Guidance literature:

With diethyl ether; anschliessenden Behandeln mit wss.HCl;

upstream raw materials:

tert-butyl isocyanide

3,4-dimethylphenylmagnesium bromide

o-xylene

pivaloyl chloride

Downstream raw materials:

1-(2-hydroxy-4,5-dimethylphenyl)-2,2-dimethylpropan-1-one

4-chloro-N-[2-(2,2-dimethyl-propionyl)-4,5-dimethyl-phenyl]-benzenesulfonamide

Toluene-4-sulfonic acid 1-(3,4-dimethyl-phenyl)-2,2-dimethyl-propyl ester

Refernces

• 1、 -. "Alkanoyl isoindolinylmethyl alkylphenones". . . Retrieved 2008/06/13.