(Methoxycarbonylmethyl)ammonium chloride

Base Information

• Chemical Name: (Methoxycarbonylmethyl)ammonium chloride
• CAS No.: 5680-79-5
• Molecular Formula: C3H8ClNO2
• Molecular Weight: 125.555
• Hs Code.: 29224995
• Mol file: 5680-79-5.mol

Synonyms:(methoxycarbonylmethyl)ammonium chloride

Chemical Property of (Methoxycarbonylmethyl)ammonium chloride

Chemical Property:

• Appearance/Colour: Crystalline
• Vapor Pressure: 79.8mmHg at 25°C
• Melting Point: 175 °C (dec.)(lit.)
• Boiling Point: 82.1 °C at 760 mmHg
• PSA: 52.32000
• Density: 1.000
• LogP: 0.62040
• Storage Temp.: -20°C
• Sensitive.: Hygroscopic
• Solubility.: >1000 g/L (20°C)
• Water Solubility.: >1000 g/L (20 ºC)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 125.0243562
• Heavy Atom Count: 7
• Complexity: 52.8

Purity/Quality:

99% ^*data from raw suppliers

Glycine methylester HCI ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC(=O)C[NH3+].[Cl-]
• Uses: A Glycine ester, a non-essential amino acid for human development. Glycine methyl ester hydrochloride a non-essential amino acid used for human development.

Technology Process of (Methoxycarbonylmethyl)ammonium chloride

There total 22 articles about (Methoxycarbonylmethyl)ammonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + glycine (56-40-6,18875-39-3,25718-94-9) → glycine ethyl ester hydrochloride (5680-79-5,883886-67-7)

Guidance literature:

With acetyl chloride; at 0 - 20 ℃;

DOI:10.1080/00397919808005101

Reference yield: 99.5%

methoxycarbonylmethylamine (616-34-2) → glycine ethyl ester hydrochloride (5680-79-5,883886-67-7)

Guidance literature:

With thionyl chloride; In methanol; at -10 ℃; for 0.166667h;

Reference yield: 90.0%

N-(Dimethoxyphosphinyl)-glycinmethylester (70036-25-8) → glycine ethyl ester hydrochloride (5680-79-5,883886-67-7)

Guidance literature:

With hydrogenchloride; In toluene; for 48h; Ambient temperature;

upstream raw materials:

methanol

(Z)-4-((carboxymethyl)amino)-4-oxobut-2-enoic acid

2-aminoethanoic acid hydrochloride

ethanol

Downstream raw materials:

N-[N,O-bis-(toluene-4-sulfonyl)-L-tyrosyl]-glycine methyl ester

methyl N-formylglycinate

N-tritylglycine methyl ester

2-(4-nitrobenzamido)acetic acid methyl ester

Refernces

• 1、 Philip, Anil K.,Dubey, Rajesh K.,Pathak, Kamla. "Optimizing delivery of flurbiprofen to the colon using a targeted prodrug approach". . p. 607 - 613. Retrieved 2008.
• 2、 Gong, Jun-Fang,Li, Xue-Hong,Song, Mao-Ping. "Microwave-Assisted Ruthenium- and Rhodium-Catalyzed Couplings of α-Amino Acid Ester-Derived Phosphinamides with Alkynes". supporting information. . Retrieved 2021/12/23.
• 3、 Guo, Peng,Wang, Ke,Jin, Wen-Jie,Xie, Hao,Qi, Liangliang,Liu, Xue-Yuan,Shu, Xing-Zhong. "Dynamic Kinetic Cross-Electrophile Arylation of Benzyl Alcohols by Nickel Catalysis". supporting information. p. 513 - 523. Retrieved 2021/01/12.