4-(Dimethylamino)-a-methyl-benzenemethanol

Base Information

• Chemical Name: 4-(Dimethylamino)-a-methyl-benzenemethanol
• CAS No.: 5338-94-3
• Molecular Formula: C19H17N5O2
• Molecular Weight: 165.235
• Hs Code.: 2922199090
• Mol file: 5338-94-3.mol

Synonyms:p-(CH3)2NC6H4C(O)CH(CH3)2;1-(4-(dimethylamino)phenyl)-2-methylpropan-1-one;1-<4-(N,N-dimethylamino)phenyl>-2-methylpropan-1-one;(N,N-dimethylamino-4)phenyl-1 ethanol;-isopropyl-keton;p-N,N-Dimethylaminoisobutyrophenon;1-[4-(N,N-dimethylamino)phenyl]ethanol;(4-Dimethylaminophenyl)-isopropylketon;1-(4-(dimethylamino)phenyl)ethyl alcohol;1-Propanone,1-[4-(dimethylamino)phenyl]-2-methyl;1-<(Dimethylamino)phenyl>ethanol;

Chemical Property of 4-(Dimethylamino)-a-methyl-benzenemethanol

Chemical Property:

• Vapor Pressure: 0.00151mmHg at 25°C
• Boiling Point: 283.2°Cat760mmHg
• Flash Point: 135.3°C
• PSA: 23.47000
• Density: 1.042g/cm³
• LogP: 1.80590

Purity/Quality:

99% ^*data from raw suppliers

1-[4-(DIMETHYLAMINO)PHENYL]ETHANOL ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(Dimethylamino)-a-methyl-benzenemethanol

There total 20 articles about 4-(Dimethylamino)-a-methyl-benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4'-dimethylaminoacetophenone (2124-31-4) → 1-[4-(N,N-dimethylamino)phenyl]ethanol (5338-94-3)

Guidance literature:

4'-dimethylaminoacetophenone; With triethyl borane; sodium methylate; In tetrahydrofuran; diethyl ether; at 20 ℃; for 4h; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; at 20 ℃; for 2h;

DOI:10.1002/chem.201502942

Reference yield: 96.0%

methylmagnesium chloride (676-58-4) + 4-dimethylamino-benzaldehyde (100-10-7) → 1-[4-(N,N-dimethylamino)phenyl]ethanol (5338-94-3)

Guidance literature:

In tetrahydrofuran; diethyl ether; for 3h; Heating;

Reference yield: 79.0%

methyl magnesium iodide (917-64-6) + 4-dimethylamino-benzaldehyde (100-10-7) → 1-[4-(N,N-dimethylamino)phenyl]ethanol (5338-94-3)

Guidance literature:

DOI:10.1021/jo00144a022

upstream raw materials:

methyl magnesium iodide

diethyl ether

4-dimethylamino-benzaldehyde

2,2,2-trifluoroethanol

Downstream raw materials:

methyl ether of 1-(4-(dimethylamino)phenyl)ethyl alcohol

1-(4-(dimethylamino)phenyl)ethyl trifluoroethyl ether

1-<4-(dimethylamino)phenyl>ethyl tert-butyl peroxide

ethyl ether of 1-(4-(dimethylamino)phenyl)ethyl alcohol

Refernces

• 1、 Bodensteiner, Michael,Coburger, Peter,Demeshko, Serhiy,Gawron, Martin,Maier, Thomas M.,Meyer, Franc,Wolf, Robert,de Bruin, Bas,van Leest, Nicolaas P.. "Low-valence anionic α-diimine iron complexes: Synthesis, characterization, and catalytic hydroboration studies". . p. 16035 - 16052. Retrieved 2020/11/20.
• 2、 -. "N, O-coordination mode rhodium complex and synthesis method and use thereof". Paragraph 0045; 0046. . Retrieved 2017/08/31.