3-Chloro-N-benzylideneaniline

Base Information

• Chemical Name: 3-Chloro-N-benzylideneaniline
• CAS No.: 7519-65-5
• Molecular Formula: C₁₃H₁₀ClN
• Molecular Weight: 215.682
• Mol file: 7519-65-5.mol

Synonyms:N-benzylidene-3-chloroaniline;3'-chloro-N-benzylideneaniline;N-Benzyliden-3-chlor-anilin;

Chemical Property of 3-Chloro-N-benzylideneaniline

Chemical Property:

• Melting Point: 35-38 °C
• Boiling Point: 348.3±25.0 °C(Predicted)
• PKA: 2.71±0.50(Predicted)
• PSA: 12.36000
• Density: 1.08±0.1 g/cm3(Predicted)
• LogP: 4.09060

Purity/Quality:

95% ^*data from raw suppliers

N-BENZYLIDENE-3-CHLOROANILINE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-N-benzylideneaniline

There total 22 articles about 3-Chloro-N-benzylideneaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzaldehyde (100-52-7) + 3-chloro-aniline (108-42-9) → N-(3-chlorobenzylidene)aniline (7519-65-5,32213-65-3)

Guidance literature:

In methanol;

DOI:10.3762/bjoc.9.109

Reference yield: 95.2%

3-chloro-aniline (108-42-9) + benzyl alcohol (100-51-6,185532-71-2) → N-(3-chlorobenzylidene)aniline (7519-65-5,32213-65-3)

Guidance literature:

With potassium hydroxide; In benzene; at 30 ℃; for 1.5h; Molecular sieve;

Reference yield: 83.0%

3-chloro-aniline (108-42-9) + benzylamine (100-46-9) → N-(3-chlorobenzylidene)aniline (7519-65-5,32213-65-3)

Guidance literature:

With [Et₃NH]2[Ru(2,6-pyridinedicarboxylate)Cl₃]; In neat (no solvent); at 100 ℃; for 14h;

DOI:10.1016/j.catcom.2016.03.019

upstream raw materials:

benzaldehyde

3-chloro-aniline

hydrobenzamide

N-(1-chlorobenzyl)pyridinium chloride

Downstream raw materials:

1-(3-chloro-phenyl)-4-phenyl-azetidin-2-one

α-Cyan-zimtsaeure-<3-chlor-anilid>

2-(3-Chloranilino)-2-phenyl-1-ethoxycarbonylethanphosphonsaeurediisopropylester

N-benzylidene-4-ethoxyaniline

Refernces

• 1、 Wang, Kai,Wei, Tingting,Zhang, Yujia,Hou, Jiahao,Bai, Renren,Xie, Yuanyuan. "Metal-free regioselective C-H amination for the synthesis of pyrazole-containing 2H-indazoles". . p. 1787 - 1794. Retrieved 2021/03/14.
• 2、 Gülcan, Mehmet,Gumus, Ilkay,Karatas, Yasar,Ruzgar, Adem. "Highly efficient and selective one-pot tandem imine synthesis via amine-alcohol cross-coupling reaction catalysed by chromium-based MIL-101 supported Au nanoparticles". . . Retrieved 2021/01/09.