Bis(4-methoxyphenyl)chloromethane

Base Information

• Chemical Name: Bis(4-methoxyphenyl)chloromethane
• CAS No.: 7525-23-7
• Molecular Formula: C15H15ClO2
• Molecular Weight: 262.736
• DSSTox Substance ID: DTXSID00443817
• Nikkaji Number: J736.348F
• Wikidata: Q82261776
• Mol file: 7525-23-7.mol

Synonyms:7525-23-7;bis(4-methoxyphenyl)chloromethane;4,4'-(Chloromethylene)bis(methoxybenzene);bis(4-methoxyphenyl)methyl chloride;1-[chloro-(4-methoxyphenyl)methyl]-4-methoxybenzene;4,4'-dimethoxybenzhydryl chloride;SCHEMBL2277677;Chlorobis(4-methoxyphenyl)methane;DTXSID00443817;YXOMWGPGGXZCKU-UHFFFAOYSA-N;bis(p-methoxyphenyl)methyl chloride;AKOS009075922;bis-(4-methoxy-phenyl)-methyl chloride;C78442;1-[chloro(4-methoxyphenyl)methyl]-4-methoxybenzene

Chemical Property of Bis(4-methoxyphenyl)chloromethane

Chemical Property:

• PSA: 18.46000
• LogP: 4.03200
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 262.0760574
• Heavy Atom Count: 18
• Complexity: 207

Purity/Quality:

99.90% ^*data from raw suppliers

Bis(4-methoxyphenyl)methylchloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)Cl

Technology Process of Bis(4-methoxyphenyl)chloromethane

There total 17 articles about Bis(4-methoxyphenyl)chloromethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4,4'-Dimethoxybenzhydrol (728-87-0) → 4,4'-dimethoxydiphenylmethyl chloride (7525-23-7)

Guidance literature:

With hydrogenchloride; calcium chloride; In dichloromethane;

DOI:10.1002/1099-0690(200207)2002:14<2411::AID-EJOC2411>3.0.CO;2-N

Reference yield: 7.0%

2,5-Dichloro-1,4-benzoquinone (615-93-0) + 4,4'-dianisylmethane (726-18-1) → 4,4'-dimethoxydiphenylmethyl chloride (7525-23-7) + diether (1062-99-3) + 3,6,4'-trichloro-bicyclohexyl-3,6,3',6'-tetraene-2,5,2',5'-tetraone

Guidance literature:

In acetonitrile; for 0.166667h; Irradiation;

DOI:10.1002/1521-3765(20010716)7:14<3005::AID-CHEM3005>3.0.CO;2-9

Reference yield:

bis(p-methoxyphenyl)methanone (90-96-0) → 4,4'-dimethoxydiphenylmethyl chloride (7525-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Zn, KOH / ethanol

2: HCl (gas), CaCl₂ / CH₂Cl₂ / 0 °C

With hydrogenchloride; potassium hydroxide; calcium chloride; zinc; In ethanol; dichloromethane;

upstream raw materials:

4,4'-Dimethoxybenzhydrol

bis(p-methoxyphenyl)methyl cation

4,4'-dimethylbenzhydrol

2,5-Dichloro-1,4-benzoquinone

Downstream raw materials:

[2-(4,4'-dimethoxy-benzhydryloxy)-ethyl]-dimethyl-amine

N-(4,4'-dimethoxybenzhydryl)aziridine

1-[bis(4-methoxyphenyl)methyl]-1H-imidazole

ethyl <4-(bis (4-methoxyphenyl) methyl)-1-piperazinyl> carboxylate

Refernces

• 1、 Hiscox, Stephen E.,Jones, Samuel R.,Kandil, Sahar B.,Smith, Sonia,Westwell, Andrew D.. "Structure-based virtual screening, synthesis and biological evaluation of potential FAK-FAT domain inhibitors for treatment of metastatic cancer". . . Retrieved 2020/08/28.
• 2、 Byrne, Peter A.,Kobayashi, Shinjiro,Würthwein, Ernst-Urich,Ammer, Johannes,Mayr, Herbert. "Why are vinyl cations sluggish electrophiles?". supporting information. p. 1499 - 1511. Retrieved 2017/02/10.