Ethyl 4-Phosphanobenzoate

Base Information

• Chemical Name: Ethyl 4-Phosphanobenzoate
• CAS No.: 75378-49-3
• Molecular Formula: C9H11O5P
• Molecular Weight: 230.15400
• Mol file: 75378-49-3.mol

Synonyms:4-Carbaethoxy-phenylphosphinsaeure;4-Phosphonobenzoic Acid 1-Ethyl Ester;Ethyl 4-Phosphanobenzoate;

Chemical Property of Ethyl 4-Phosphanobenzoate

Chemical Property:

• PSA: 93.64000
• LogP: 0.66630

Purity/Quality:

95%-98% ^*data from raw suppliers

4-PhosphonobenzoicAcid1-EthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Oxidative Heck-Type reaction involving cleavage of a carbon-phosphorus bond of arylphosphonic acids.

Technology Process of Ethyl 4-Phosphanobenzoate

There total 2 articles about Ethyl 4-Phosphanobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl (4-ethoxycarbonylphenyl)phosphonate (17067-92-4) → (4-ethoxycarbonyl-phenyl)-phosphonic acid (75378-49-3)

Guidance literature:

diethyl (4-ethoxycarbonylphenyl)phosphonate; With trimethylsilyl bromide; In acetonitrile; at 20 ℃; for 3h;

With water; In diethyl ether; at 20 ℃; for 0.5h; Further stages.;

DOI:10.1021/ja026758v

Reference yield:

ethanol (64-17-5) + 4-phosphonbenzoic acid (618-21-3) → (4-ethoxycarbonyl-phenyl)-phosphonic acid (75378-49-3)

Guidance literature:

With hydrogenchloride;

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + (4-ethoxycarbonyl-phenyl)-phosphonic acid (75378-49-3) → (E)-ethyl 4-styrylbenzoate (1152-30-3,109463-49-2,109463-48-1)

Guidance literature:

With trimethylamine-N-oxide; tetrabutyl ammonium fluoride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; at 100 ℃; for 24h;

DOI:10.1021/ja026758v

upstream raw materials:

ethanol

4-phosphonbenzoic acid

diethyl (4-ethoxycarbonylphenyl)phosphonate

Downstream raw materials:

(E)-ethyl 4-styrylbenzoate

ethyl 4-((1E)-3-tert-butoxy-3-oxoprop-1-en-1-yl)benzoate

Refernces