(5-HYDROXY-1-BENZOFURAN-3-YL)(PHENYL)METHANONE

Base Information

• Chemical Name: (5-HYDROXY-1-BENZOFURAN-3-YL)(PHENYL)METHANONE
• CAS No.: 17249-62-6
• Molecular Formula: C15H10 O3
• Molecular Weight: 238.243
• Hs Code.: 2932999099
• Mol file: 17249-62-6.mol

Synonyms:Ketone,5-hydroxy-3-benzofuranyl phenyl (8CI)

Chemical Property of (5-HYDROXY-1-BENZOFURAN-3-YL)(PHENYL)METHANONE

Chemical Property:

• Vapor Pressure: 1.5E-07mmHg at 25°C
• Melting Point: 182-184°C
• Boiling Point: 417.1°Cat760mmHg
• PKA: 8.35±0.40(Predicted)
• Flash Point: 206.1°C
• PSA: 50.44000
• Density: 1.302g/cm³
• LogP: 3.36940

Purity/Quality:

98%min ^*data from raw suppliers

(5-Hydroxy-1-benzofuran-3-yl)(phenyl)methanone >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-HYDROXY-1-BENZOFURAN-3-YL)(PHENYL)METHANONE

There total 2 articles about (5-HYDROXY-1-BENZOFURAN-3-YL)(PHENYL)METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-phenyl-3-dimethylaminoprop-2-enone (1201-93-0) + p-benzoquinone (106-51-4) → (5-hydroxy-benzofuran-3-yl)-phenyl-methanone (17249-62-6)

Guidance literature:

With Amberlyst-15in PEG 400; at 20 ℃; for 0.166667h; Reagent/catalyst; Green chemistry;

DOI:10.2174/1570178614666170329151935

Reference yield:

acetophenone (98-86-2) → (5-hydroxy-benzofuran-3-yl)-phenyl-methanone (17249-62-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 20 h / 150 °C / Inert atmosphere

2: acetic acid / 5 h / 20 °C / Inert atmosphere

With acetic acid; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.05.129

Reference yield: 100.0%

(5-hydroxy-benzofuran-3-yl)-phenyl-methanone (17249-62-6) + acetic anhydride (108-24-7) → Acetic acid 3-benzoyl-benzofuran-5-yl ester (344868-28-6)

Guidance literature:

With sulfuric acid; for 2h; Ambient temperature;

DOI:10.1007/BF00505747

upstream raw materials:

1-phenyl-3-dimethylaminoprop-2-enone

p-benzoquinone

acetophenone

Downstream raw materials:

(4-Chloro-5-hydroxy-benzofuran-3-yl)-phenyl-methanone

(4-Bromo-5-hydroxy-benzofuran-3-yl)-phenyl-methanone

(4,6-Dibromo-5-hydroxy-benzofuran-3-yl)-phenyl-methanone

(5-Hydroxy-4,6-dinitro-benzofuran-3-yl)-phenyl-methanone

Refernces

• 1、 Antczak, Christophe,Shum, David,Bassit, Bhramdeo,Frattini, Mark G.,Li, Yueming,Stanchina, Elisa De,Scheinberg, David A.,Djaballah, Hakim. "Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase". supporting information; experimental part. p. 4528 - 4532. Retrieved 2011/09/12.