Propanedioic acid, (4-methoxybenzoyl)-, diethyl ester

Base Information

• Chemical Name: Propanedioic acid, (4-methoxybenzoyl)-, diethyl ester
• CAS No.: 75907-18-5
• Molecular Formula: C15H18O6
• Molecular Weight: 294.304
• Mol file: 75907-18-5.mol

Synonyms:

Chemical Property of Propanedioic acid, (4-methoxybenzoyl)-, diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanedioic acid, (4-methoxybenzoyl)-, diethyl ester

There total 6 articles about Propanedioic acid, (4-methoxybenzoyl)-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-methoxy-benzoyl chloride (100-07-2) + diethyl malonate (105-53-3) → diethyl 2-(4-methoxybenzoyl)malonate (75907-18-5)

Guidance literature:

diethyl malonate; With ethanol; magnesium; In tetrachloromethane; toluene; for 1h; Heating;

4-methoxy-benzoyl chloride; In tetrachloromethane; toluene; at 20 ℃; for 1h;

DOI:10.1081/SCC-120015395

Reference yield: 72.0%

4-methoxy-benzoyl chloride (100-07-2) + acetylacetone (123-54-6,81235-32-7) → diethyl 2-(4-methoxybenzoyl)malonate (75907-18-5)

Guidance literature:

With samarium(III) chloride; triethylamine; In toluene; at 20 ℃; for 4h;

DOI:10.1021/ol701961z

Reference yield: 71.0%

carbon monoxide (201230-82-2) + 4-methoxyphenylboronic acid (5720-07-0) + diethyl malonate (105-53-3) → diethyl 2-(4-methoxybenzoyl)malonate (75907-18-5)

Guidance literature:

diethyl malonate; With lithium tert-butoxide; In toluene; at 20 ℃; for 1h; Autoclave;

carbon monoxide; 4-methoxyphenylboronic acid; With palladium(II) trifluoroacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; silver(l) oxide; In toluene; at 20 - 80 ℃; for 12h; under 3800.26 Torr; Autoclave;

DOI:10.1039/c4ob00568f

upstream raw materials:

2-[Hydroxy-(4-methoxy-phenyl)-methylene]-malonic acid diethyl ester

4-methoxy-benzoyl chloride

diethyl malonate

acetylacetone

Downstream raw materials:

2-[Hydroxy-(4-methoxy-phenyl)-methylene]-malonic acid diethyl ester

p-Brom-benzolsulfonsaeure-<1-p-anisoyl-2,2-diaethoxycarbonyl-vinylester>

7,8-dihydroxy-4-(4-methoxyphenyl)-2H-chromen-2-one

7-hydroxy-4-(4-methoxyphenyl)-2H-chromen-2-one

Refernces

• 1、 Fu, Lei,Liu, Yuke,Lu, Yu,Sheng, Li,Wang, Bin,Zhang, Dongfeng,Zhao, Hongyi,Zhao, Wenting. "Design, synthesis, and biological evaluation of novel 4H-chromen-4-one derivatives as antituberculosis agents against multidrug-resistant tuberculosis". . . Retrieved 2020/01/28.
• 2、 Shen, Quansheng,Huang, Wen,Wang, Jialiang,Zhou, Xigeng. "SmCl3-catalyzed C-acylation of 1,3-dicarbonyl compounds and malononitrile". . p. 4491 - 4494. Retrieved 2008/03/12.