Ethyl 1-methylhydrazinecarboxylate

Base Information

• Chemical Name: Ethyl 1-methylhydrazinecarboxylate
• CAS No.: 760-81-6
• Molecular Formula: C4H10N2O2
• Molecular Weight: 118.13400
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID80458964
• Wikidata: Q82282542
• Mol file: 760-81-6.mol

Synonyms:ethyl 1-methylhydrazinecarboxylate;760-81-6;ethyl N-amino-N-methylcarbamate;N-methylethoxycarbohydrazide;2-azaalanine ethyl ester;N-carbethoxy-N-methylhydrazine;SCHEMBL7664573;ethyl1-methylhydrazinecarboxylate;DTXSID80458964;GFIGIXMFDHSXBF-UHFFFAOYSA-N;Ethyl 1-methylhydrazine carboxylate;MFCD18431358;AKOS015997894;LS-06923;EN300-321297

Chemical Property of Ethyl 1-methylhydrazinecarboxylate

Chemical Property:

• Boiling Point: 40 °C(Press: 0.05 Torr)
• PKA: 3.28±0.10(Predicted)
• PSA: 55.56000
• Density: 1.084±0.06 g/cm3(Predicted)
• LogP: 0.64870
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 118.074227566
• Heavy Atom Count: 8
• Complexity: 84.1

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl 1-methylhydrazinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)N(C)N

Technology Process of Ethyl 1-methylhydrazinecarboxylate

There total 6 articles about Ethyl 1-methylhydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

chloroformic acid ethyl ester (541-41-3) + methylhydrazine (60-34-4) → ethyl 2-methylcarbazate (760-81-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jm049556d

Reference yield:

chloroformic acid ethyl ester (541-41-3) + methylhydrazine (60-34-4) → 2-azaalanine ethyl ester (760-81-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; chloroform;

Reference yield:

chloroformic acid ethyl ester (541-41-3) → ethyl 2-methylcarbazate (760-81-6)

Guidance literature:

With sodium chloride;

upstream raw materials:

ethanol

methyl-(1-methyl-2-oxo-propylidene)-carbazic acid ethyl ester

chloroformic acid ethyl ester

methylhydrazine

Downstream raw materials:

methyl-(2-nitro-benzylidene)-carbazic acid ethyl ester

1-ethoxycarbonyl-1-methyl-2-(1-phenylhydrazonopropan-2-one)hydrazine

1-ethoxycarbonyl-1-methyl-2-[1-(4-bromophenyl)hydrazonopropan-2-one]hydrazine

1-ethoxycarbonyl-1-methyl-2-[1-(4-methylphenyl)hydrazonopropan-2-one]hydrazine

Refernces

• 1、 Wanner, Martin J.,Koch, Melle,Koomen, Gerrit-Jan. "Synthesis and antitumor activity of methyltriazene prodrugs simultaneously releasing DNA-methylating agents and the antiresistance drug O 6-benzylguanine". . p. 6875 - 6883. Retrieved 2007/10/03.
• 2、 -. "Triazolone derivatives, use thereof, and intermediates therefor". . . Retrieved 2008/06/13.