2-Propenal, 3-(dimethylamino)-2-fluoro-

Base Information

• Chemical Name: 2-Propenal, 3-(dimethylamino)-2-fluoro-
• CAS No.: 761-88-6
• Molecular Formula: C5H8FNO
• Molecular Weight: 117.123
• Mol file: 761-88-6.mol

Synonyms:2-Fluor-3-dimethylamino-propenal;3-dimethylamino-2-fluoro-propenal;

Chemical Property of 2-Propenal, 3-(dimethylamino)-2-fluoro-

Chemical Property:

• Boiling Point: 92-94 °C(Press: 0.4 Torr)
• PSA: 20.31000
• Density: 1.022±0.06 g/cm3(Predicted)
• LogP: 0.55780

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenal, 3-(dimethylamino)-2-fluoro-

There total 4 articles about 2-Propenal, 3-(dimethylamino)-2-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(Z)-(2,3,3-trifluoro-l-propenyl)trimethylammonium iodide (128229-03-8) + dimethyl amine (124-40-3) → 1,1,5,5-Tetramethyl-1,5-diaza-3-fluoropentadienium iodide (139680-71-0) + β-(Dimethylamino)-α-fluoropropenal (761-88-6,152873-63-7)

Guidance literature:

In dimethyl sulfoxide; for 3h; Ambient temperature;

DOI:10.1016/S0040-4039(00)74130-X

Reference yield: 40.0%

sodium fluoroacetate (62-74-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → (Z)-3-(dimethylamino)-2-fluoroacrylaldehyde (761-88-6,152873-63-7)

Guidance literature:

sodium fluoroacetate; N,N-dimethyl-formamide; With oxalyl dichloride; at 0 - 60 ℃; for 1h; Inert atmosphere;

With triethylamine; In N,N-dimethyl-formamide; at 55 ℃; for 1h; Cooling with ice; Inert atmosphere;

DOI:10.1002/jlcr.1887

Reference yield: 24.0%

sodium fluoroacetate (62-74-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → β-(Dimethylamino)-α-fluoropropenal (761-88-6,152873-63-7)

Guidance literature:

sodium fluoroacetate; N,N-dimethyl-formamide; With oxalyl dichloride; at 0 - 60 ℃;

With triethylamine; at 0 - 50 ℃; for 1.33333h;

With water; potassium carbonate; at 0 - 80 ℃;

DOI:10.1016/j.tetlet.2010.03.080

upstream raw materials:

sodium fluoroacetate

N,N-dimethyl-formamide

(Z)-(2,3,3-trifluoro-l-propenyl)trimethylammonium iodide

dimethyl amine

Downstream raw materials:

ethyl 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylate

4-fluoro-1H-pyrazole

Refernces

• 1、 -. "SUBSTITUTED PYRIMIDINES". Page/Page column 87; 88. . Retrieved 2013/04/10.
• 2、 England, Katherine,Mason, Helen,Osborne, Rachel,Roberts, Lee. "An improved synthesis of a novel α1A partial agonist including a new two-step synthesis of 4-fluoropyrazole". experimental part. p. 2849 - 2851. Retrieved 2010/07/06.