2-(2-Methoxyethoxy)acetic acid

Base Information

• Chemical Name: 2-(2-Methoxyethoxy)acetic acid
• CAS No.: 16024-56-9
• Molecular Formula: C5H10O4
• Molecular Weight: 134.132
• Hs Code.: 2918990090
• European Community (EC) Number: 240-161-6
• NSC Number: 127858
• DSSTox Substance ID: DTXSID90166841
• Nikkaji Number: J219.941F
• Wikidata: Q26840902
• Mol file: 16024-56-9.mol

Synonyms:(2-methoxyethoxy)acetic acid;MEAA acid

Chemical Property of 2-(2-Methoxyethoxy)acetic acid

Chemical Property:

• Appearance/Colour: Colorless Or Straw yellow liquid
• Vapor Pressure: 0.00651mmHg at 25°C
• Refractive Index: n20/D 1.436(lit.)
• Boiling Point: 251.3 °C at 760 mmHg
• PKA: 3.40±0.10(Predicted)
• Flash Point: 106.4 °C
• PSA: 55.76000
• Density: 1.132 g/cm³
• LogP: -0.26600
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Fully miscible in water.
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 134.05790880
• Heavy Atom Count: 9
• Complexity: 81

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Methoxyethoxy)aceticAcid(90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COCCOCC(=O)O

Technology Process of 2-(2-Methoxyethoxy)acetic acid

There total 7 articles about 2-(2-Methoxyethoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-(2-methoxyethoxy)ethyl alcohol (111-77-3,95507-80-5) → 2-(2-methoxyethoxy)acetic acid (16024-56-9)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; sodium carbonate; at 20 ℃; for 2.5h; Electrochemical reaction;

DOI:10.1055/s-2007-991070

Reference yield: 88.2%

C9H18O4 → 2-(2-methoxyethoxy)acetic acid (16024-56-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 - 25 ℃; for 72h;

Reference yield: 60.97%

3,6-dioxaheptanoic acid ethyl ester (57982-39-5) → 2-(2-methoxyethoxy)acetic acid (16024-56-9)

Guidance literature:

With methanol; potassium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;

upstream raw materials:

2-(2-methoxyethoxy)ethyl alcohol

diethylene glycol dimethyl ether

chloroacetic acid

2-methoxy-ethanol

Downstream raw materials:

benzhydryl 2-(2-methoxyethoxy)acetate

t-butyl (5-{5-[(2-methoxyethoxy)methyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)carbamate

4-benzyl-4-methylmorpholinium 2-(2-methoxyethoxy)acetate

C₁₁H₁₅NO₄

Refernces

• 1、 -. "NOVEL TRITERPENE DERIVATIVES AS HIV INHIBITORS". Page/Page column 51. . Retrieved 2020/08/28.
• 2、 -. "OPIOID AGONISTS AND USES THEREOF". Paragraph 00261. . Retrieved 2015/06/11.