RP 48497 (Eszopiclone Impurity C)

Base Information

• Chemical Name: RP 48497 (Eszopiclone Impurity C)
• CAS No.: 148891-53-6
• Molecular Formula: C11H7 Cl N4 O
• Molecular Weight: 246.6525
• Mol file: 148891-53-6.mol

Synonyms:RP 48497

Chemical Property of RP 48497 (Eszopiclone Impurity C)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 226-228°C
• Boiling Point: 469.435°C at 760 mmHg
• PKA: -0.63±0.29(Predicted)
• Flash Point: 237.706°C
• PSA: 58.98000
• Density: 1.524g/cm³
• LogP: 1.75040
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

RP48497(EszopicloneImpurityC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Eszopiclone Impurity C.

Technology Process of RP 48497 (Eszopiclone Impurity C)

There total 3 articles about RP 48497 (Eszopiclone Impurity C) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.6%

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one (43200-81-3,537036-14-9) → 6-(5-chloropyridin-2-yl)-6,7-dihydropyrrolo[3,4-b]pyrazin-5-one (148891-53-6)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -15 ℃; for 2h; Temperature;

Reference yield: 91.1%

6-(5-chloro-2-pyridyl)-5,7-dioxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazine (43200-82-4) → 6-(5-chloropyridin-2-yl)-6,7-dihydropyrrolo[3,4-b]pyrazin-5-one (148891-53-6)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -25 - -10 ℃; for 2h; Temperature; Solvent;

Reference yield:

3-chloromethylpyrazine-2-carboxylic acid N-(5-chloro-pyridin-2-yl)-amide (1122549-47-6) → 6-(5-chloropyridin-2-yl)-6,7-dihydropyrrolo[3,4-b]pyrazin-5-one (148891-53-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.3390/molecules13081817

upstream raw materials:

3-chloromethylpyrazine-2-carboxylic acid N-(5-chloro-pyridin-2-yl)-amide

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

6-(5-chloro-2-pyridyl)-5,7-dioxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazine

Refernces

• 1、 Sha, Yu,Zhang, Lei,Du, Gui-Jie,Ren, Jian,Cheng, Mao-Sheng. "Synthesis of RP 48497, an impurity of eszopiclone". . p. 1817 - 1821. Retrieved 2008/12/22.