N-BENZYLGLYCINE TERT-BUTYL ESTER

Base Information

• Chemical Name: N-BENZYLGLYCINE TERT-BUTYL ESTER
• CAS No.: 7662-76-2
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.299
• Hs Code.: 2922499990
• Mol file: 7662-76-2.mol

Synonyms:Benzylaminoacetic acid tert-butyl ester;

Chemical Property of N-BENZYLGLYCINE TERT-BUTYL ESTER

Chemical Property:

• Boiling Point: 151-152 °C(Press: 12 Torr)
• PKA: 6?+-.0.20(Predicted)
• PSA: 38.33000
• Density: 1.019±0.06 g/cm3(Predicted)
• LogP: 2.50880

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl2-(Benzylamino)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl 2-(Benzylamino)acetate is a useful compound for studying structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors.

Technology Process of N-BENZYLGLYCINE TERT-BUTYL ESTER

There total 13 articles about N-BENZYLGLYCINE TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

bromoacetic acid tert-butyl ester (5292-43-3) + benzylamine (100-46-9) → tert-butyl 2-(benzylamino)acetate (7662-76-2)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tet.2018.06.056

Reference yield: 87.0%

tert-butyl 2-[N-benzyl-N-(tertbutoxycarbonyl)amino]acetate → tert-butyl 2-(benzylamino)acetate (7662-76-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1002/chem.201402514

Reference yield: 82.0%

[(benzothiazole-2-sulfonyl)-benzyl-amino]-acetic acid tert-butyl ester → tert-butyl 2-(benzylamino)acetate (7662-76-2)

Guidance literature:

With potassium tert-butylate; thiophenol; In tetrahydrofuran; N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0040-4039(98)02107-8

upstream raw materials:

bromoacetic acid tert-butyl ester

benzylamine

Glycine tert-butyl ester

benzaldehyde

Downstream raw materials:

ethyl 2-[[[2-(1,1-dimethylethoxy)-2-oxoethyl](phenylmethyl)amino]methyl]-3-pyridinecarboxylate

N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester

N-benzyl-N-[(1,4-dichloro-7-isoquinolinyl)methyl]glycine t-butyl ester

4-[(benzyl-tert-butoxycarbonylmethyl-amino)-methyl]-3-bromo-benzoic acid methyl ester

Refernces

• 1、 Shi, Xingpeng,Quan, Yanni,Wang, Yixuan,Wang, Ying,Li, Yanping. "Design, synthesis, and biological evaluation of 2,6,7-substituted pyrrolo[2,3-d]pyrimidines as cyclin dependent kinase inhibitor in pancreatic cancer cells". supporting information. . Retrieved 2020/12/29.
• 2、 -. "PEPTOID-BASED CHELATING LIGANDS FOR SELECTIVE METAL CHELATION". Paragraph 0075-0076. . Retrieved 2020/04/29.