Phe-Pro

Base Information

• Chemical Name: Phe-Pro
• CAS No.: 7669-65-0
• Molecular Formula: C14H18N2O3
• Molecular Weight: 262.309
• Hs Code.: 2933990090
• Nikkaji Number: J661.079J,J661.080C,J81.436I
• Wikidata: Q27144877
• Metabolomics Workbench ID: 78930
• ChEMBL ID: CHEMBL1807686
• Mol file: 7669-65-0.mol

Synonyms:D-Phe-Pro;L-Phe-Pro;phenylalanylproline

Chemical Property of Phe-Pro

Chemical Property:

• Melting Point: 127-129℃
• PSA: 83.63000
• LogP: 1.27020
• Storage Temp.: −20°C
• XLogP3: -1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 262.13174244
• Heavy Atom Count: 19
• Complexity: 340

Purity/Quality:

98%Min ^*data from raw suppliers

Phe-Pro ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC(N(C1)C(=O)C(CC2=CC=CC=C2)N)C(=O)O
• Isomeric SMILES: C1C[C@H](N(C1)C(=O)[C@H](CC2=CC=CC=C2)N)C(=O)O
• Recent ClinicalTrials: Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude
• Recent EU Clinical Trials: A 12-Week, Randomized, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of Fluticasone Propionate Multidose Dry Powder Inhaler Compared with Fluticasone Propionate/Salmeterol Multidose Dry Powder Inhaler in Patients Aged 4 Through 11 Years with Persistent Asthma

Technology Process of Phe-Pro

There total 9 articles about Phe-Pro which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-tyrosyl-L-prolyl-L-phenylalanyl-L-prolyl-glycyl-L-prolyl-L-isoleucine (72122-62-4) → H-Tyr-Pro-OH (51871-47-7) + L-phenylalanyl-L-proline (7669-65-0,28819-11-6) + Gly-Pro-Ile (89187-15-5) + H-Gly-Pro-OH (704-15-4)

Guidance literature:

at 37 ℃; for 7h; Yield given. Yields of byproduct given; 0.1 M Tris HCl buffer pH 8.0, X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis subsp. cremoris nTR;

DOI:10.1271/bbb.56.704

Reference yield:

L-tyrosyl-L-prolyl-L-phenylalanyl-L-prolyl-glycyl-L-prolyl-L-isoleucine (72122-62-4) → H-Tyr-Pro-OH (51871-47-7) + L-phenylalanyl-L-proline (7669-65-0,28819-11-6) + Gly-Pro-Ile (89187-15-5) + Phe-Pro-Gly-Pro-Ile + H-Gly-Pro-OH (704-15-4)

Guidance literature:

at 37 ℃; Kinetics; 0.1 M Tris HCl buffer pH 8.0, X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis subsp. cremoris nTR;

DOI:10.1271/bbb.56.704

Reference yield:

Fmoc-Pro-OH (71989-31-6) + N-Fmoc L-Phe (35661-40-6) → L-phenylalanyl-L-proline (7669-65-0,28819-11-6)

Guidance literature:

Fmoc-Pro-OH; With 1-methyl-1H-imidazole; diisopropyl-carbodiimide; at 20 ℃; for 2h; Green chemistry;

With piperidine; In N,N-dimethyl-formamide; for 0.133333h; Green chemistry;

N-Fmoc L-Phe; Further stages; Green chemistry;

DOI:10.1016/j.tetlet.2019.151058

upstream raw materials:

L-tyrosyl-L-prolyl-L-phenylalanyl-L-prolyl-glycyl-L-prolyl-L-isoleucine

Phe-Pro-NHPh

glycine

Fmoc-Phe-Pro-OH

Refernces

• 1、 Liu, Zhijian,Yasuda, Nobuyoshi,Simeone, Michael,Reamer, Robert A.. "N -boc deprotection and isolation method for water-soluble zwitterionic compounds". . p. 11792 - 11796. Retrieved 2015/02/19.
• 2、 Yan,Ho,Hou. "Catalytic properties of X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis subsp. cremoris nTR.". . p. 704 - 707. Retrieved 2007/10/02.