3-Morpholin-4-Yl-Propionic Acid Hydrochloride

Base Information

• Chemical Name: 3-Morpholin-4-Yl-Propionic Acid Hydrochloride
• CAS No.: 6319-95-5
• Molecular Formula: C7H14ClNO3
• Molecular Weight: 195.646
• Hs Code.: 29349990
• European Community (EC) Number: 673-920-9
• NSC Number: 32028
• DSSTox Substance ID: DTXSID50375038
• ChEMBL ID: CHEMBL1538807
• Mol file: 6319-95-5.mol

Synonyms:6319-95-5;3-Morpholin-4-Yl-Propionic Acid Hydrochloride;3-Morpholinopropanoic acid hydrochloride;3-morpholin-4-yl-propionic acid hcl;3-(morpholin-4-yl)propanoic acid hydrochloride;4-Morpholinepropanoic acid, hydrochloride;3-morpholin-4-ylpropanoic acid;hydrochloride;MFCD00810444;3-(4-morpholinyl)propanoic acid hydrochloride;MLS000072275;3-Morpholin-4-yl-propionic acid x HCl;3-morpholin-4-ylpropanoic acid hydrochloride;3-(Morpholin-4-yl)propionic acid hydroChloride;Cambridge id 5215011;4-Morpholinepropanoic acid HCl;SCHEMBL1094998;CHEMBL1538807;DTXSID50375038;JLAHMPKUDAJSKA-UHFFFAOYSA-N;NSC32028;3-Morpholinopropanoicacidhydrochloride;NSC-32028;AKOS000113699;AS-10706;SMR000012618;FT-0636093;EN300-64163;F11751;A834262;Z57683745;F1929-1771;3-(Morpholin-4-yl)propanoic acid--hydrogen chloride (1/1)

Chemical Property of 3-Morpholin-4-Yl-Propionic Acid Hydrochloride

Chemical Property:

• Vapor Pressure: 0.000286mmHg at 25°C
• Boiling Point: 299.2 °C at 760 mmHg
• Flash Point: 134.8 °C
• PSA: 49.77000
• LogP: 0.53320
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 195.0662210
• Heavy Atom Count: 12
• Complexity: 132

Purity/Quality:

99.0%Min ^*data from raw suppliers

3-(4-MORPHOLINYL)PROPANOIC ACID HYDROCHLORIDE ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CCC(=O)O.Cl

Technology Process of 3-Morpholin-4-Yl-Propionic Acid Hydrochloride

There total 2 articles about 3-Morpholin-4-Yl-Propionic Acid Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-morpholinopropionate (20120-24-5) → 3-morpholin-4-yl-propionic acid hydrochloride (6319-95-5)

Guidance literature:

With hydrogenchloride; In water; for 6h; Heating;

DOI:10.1016/S0022-2860(00)00754-7

Reference yield:

→ 3-morpholin-4-yl-propionic acid hydrochloride (6319-95-5)

Guidance literature:

3-Morpholino-propionsaeure-trimethylester (??) u. HCl in Ae.;

DOI:10.1021/jo01350a015

Reference yield: 88.0%

4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carboxylic acid hydrazide (944343-01-5) + 3-morpholin-4-yl-propionic acid hydrochloride (6319-95-5) → 4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carboxylic acid N'-(3-morpholin-4-yl-propionyl)-hydrazide (944343-02-6)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

upstream raw materials:

ethyl 3-morpholinopropionate

Downstream raw materials:

4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carboxylic acid N'-(3-morpholin-4-yl-propionyl)-hydrazide

4-acetamidophenyl 3-morpholinopropanoate hydrochloride

C₃₅H₄₃I₂N₃O₇

C₃₃H₃₉N₇O₆S₂

Refernces

• 1、 Dega-Szafran,Ga?szczyk,Maciejewska,Szafran,Tykarska,Wawer. "13C CP MAS NMR, FTIR, X-ray diffraction and PM3 studies of some N-(ω-carboxyalkyl)morpholine hydrohalides". . p. 261 - 273. Retrieved 2007/10/03.