3-nitro-2-phenoxypyridine

Base Information

• Chemical Name: 3-nitro-2-phenoxypyridine
• CAS No.: 76893-44-2
• Molecular Formula: C11H8N2O3
• Molecular Weight: 216.196
• Mol file: 76893-44-2.mol

Synonyms:3-nitro-2-phenoxypyridine;3-nitro-2-phenoxy-pyridine;3-Nitro-2-phenoxy-pyridin;

Chemical Property of 3-nitro-2-phenoxypyridine

Chemical Property:

• Melting Point: 94-94.5 °C(Solv: ethanol (64-17-5))
• Boiling Point: 329.9±27.0 °C(Predicted)
• PKA: -1.49±0.22(Predicted)
• PSA: 67.94000
• Density: 1.309±0.06 g/cm3(Predicted)
• LogP: 3.30530

Purity/Quality:

99%min. ^*data from raw suppliers

3-Nitro-2-phenoxypyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-nitro-2-phenoxypyridine

There total 6 articles about 3-nitro-2-phenoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + phenol (108-95-2,27073-41-2) → 3-nitropyridine-2-phenyl ether (76893-44-2)

Guidance literature:

With sodium hydride; In toluene; for 3.5h; Reflux;

DOI:10.1016/j.bmcl.2010.10.004

Reference yield: 75.0%

2-fluoro-3-nitropyridine (1480-87-1) + phenylsilane (694-53-1) → 3-nitropyridine-2-phenyl ether (76893-44-2)

Guidance literature:

With carbon dioxide; palladium diacetate; caesium carbonate; In acetonitrile; at 25 ℃; for 24h; under 760.051 Torr;

Reference yield: 48.0%

diphenyl(trifluoromethanesulfonato)-λ3-iodane + 3-nitropyridone (6332-56-5) → 3-nitro-1-phenylpyridin-2(1H)-one + 3-nitropyridine-2-phenyl ether (76893-44-2)

Guidance literature:

With caesium carbonate; In 1,2-dichloro-ethane; at 120 ℃;

DOI:10.1055/s-0036-1591884

upstream raw materials:

2-Chloro-3-nitropyridine

potassium phenolate

phenolate

phenol

Downstream raw materials:

C₂₁H₁₉BrN₂O₃

C₂₁H₁₉⁽¹⁸⁾FN₂O₃

N-[2-(2-fluoroethoxy)benzyl]-N-(2-phenoxy pyridin-3-yl)acetamide

N-[2-(2-fluoroethoxy)-5-methoxybenzyl]-N-(2-phenoxypyridin-3-yl)acetamide

Refernces

• 1、 -. "Method for preparing diarylether compound based on CO2 participated C-F bond activation". Paragraph 0016-0019. . Retrieved 2021/01/04.
• 2、 Guo, Sigen,Zhong, Xinran,Gong, Bowen,Cui, Hongming,Xiang, Jinbao. "Synthesis of pyrido[2,3-b][1,4]benzoxazepines via a Friedel-Crafts cyclization". . p. 326 - 330. Retrieved 2016/12/30.