CHLOROFORMIC ACID 2-NAPHTHYL ESTER

Base Information

• Chemical Name: CHLOROFORMIC ACID 2-NAPHTHYL ESTER
• CAS No.: 7693-50-7
• Molecular Formula: C11H7ClO2
• Molecular Weight: 206.628
• Hs Code.: 2915900090
• Mol file: 7693-50-7.mol

Synonyms:naphthalen-2-yl carbonochloridate;

Chemical Property of CHLOROFORMIC ACID 2-NAPHTHYL ESTER

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 62oC
• Boiling Point: 112oC / 1mmHg
• Flash Point: 165.234oC
• PSA: 26.30000
• Density: 1.324g/cm3
• LogP: 3.57740
• Solubility.: soluble in Toluene

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Naphthyl Chloroformate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 23/24/25-34-41
• Safety Statements: 22-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Naphthyl Chloroformate is a useful reactant for the preparation of diazabicyclononane phenylcarbamates as α7 nicotinic acetylcholine receptor (nAChR) agonists.

Technology Process of CHLOROFORMIC ACID 2-NAPHTHYL ESTER

There total 6 articles about CHLOROFORMIC ACID 2-NAPHTHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

phosgene (75-44-5) + β-naphthol (135-19-3) → 2-naphthyl chloroformate (7693-50-7)

Guidance literature:

With N,N-dimethyl-aniline; In toluene; at 0 - 20 ℃; for 12h;

DOI:10.1002/(SICI)1522-2675(20000510)83:5<1022::AID-HLCA1022>3.0.CO;2-Y

Reference yield: 75.0%

β-naphthol (135-19-3) → 2-naphthyl chloroformate (7693-50-7)

Guidance literature:

With CoCl₂; triphenylphosphine;

Reference yield:

bis(trichloromethyl) carbonate (32315-10-9) + β-naphthol (135-19-3) → 2-naphthyl chloroformate (7693-50-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 50 ℃; for 1h; Inert atmosphere;

DOI:10.1002/chem.201303241

upstream raw materials:

quinoline

phosgene

β-naphthol

benzene

Downstream raw materials:

C₃₉H₅₀N₆O₇

C₂₁H₁₈N₂O₃

2-naphthyl {4-[({4-[(tert-butoxycarbonyl)amino]-1-phenyl-1H-pyrazol-3-yl}amino)carbonyl]benzyl}carbamate

2-hydroxy-N-phenylnaphthalene-1-carboxamide

Refernces

• 1、 Chang, Sukbok,Jung, Hoimin,Kim, Dongwook,Lee, Jeonghyo,Lee, Jia,Park, Juhyeon. "Versatile Cp*Co(III)(LX) Catalyst System for Selective Intramolecular C-H Amidation Reactions". supporting information. p. 12324 - 12332. Retrieved 2020/08/06.
• 2、 Ortar, Giorgio,Cascio, Maria Grazia,De Petrocellis, Luciano,Morera, Enrico,Rossi, Francesca,Schiano-Moriello, Aniello,Nalli, Marianna,De Novellis, Vito,Woodward, David F.,Maione, Sabatino,Di Marzo, Vincenzo. "New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain". . p. 6554 - 6569. Retrieved 2008/09/17.