2-(3-CHLOROBENZOYL)PYRROLE

Base Information

• Chemical Name: 2-(3-CHLOROBENZOYL)PYRROLE
• CAS No.: 7697-48-5
• Molecular Formula: C11H8ClNO
• Molecular Weight: 205.644
• Mol file: 7697-48-5.mol

Synonyms:

Chemical Property of 2-(3-CHLOROBENZOYL)PYRROLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 352.215oC at 760 mmHg
• Flash Point: 166.814oC
• PSA: 32.86000
• Density: 1.303g/cm3
• LogP: 2.89910

Purity/Quality:

98%min ^*data from raw suppliers

2-(3-CHLOROBENZOYL)PYRROLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-CHLOROBENZOYL)PYRROLE

There total 3 articles about 2-(3-CHLOROBENZOYL)PYRROLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

pyrrole (109-97-7,30604-81-0) + m-Chlorobenzoyl chloride (618-46-2) → (3-chlorophenyl)(1H-pyrrol-2-yl)methanone (7697-48-5)

Guidance literature:

With aluminium trichloride; Heating;

DOI:10.1002/jhet.5570400504

Reference yield:

3-chlorobenzoate (535-80-8) → (3-chlorophenyl)(1H-pyrrol-2-yl)methanone (7697-48-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: 57 percent / AlCl₃ / Heating

With aluminium trichloride; thionyl chloride; 2: Friedels-Crafts benzoylation;

DOI:10.1002/jhet.5570400504

Reference yield:

→ (3-chlorophenyl)(1H-pyrrol-2-yl)methanone (7697-48-5)

Guidance literature:

Pyrrol, 1) EtMgBr, 2) 3-Chlorbenzoylchlorid;

upstream raw materials:

pyrrole

m-Chlorobenzoyl chloride

3-chlorobenzoate

Downstream raw materials:

ethyl {2-[(3-chlorophenyl)carbonyl]-1H-pyrrol-1-yl}acetate

Refernces

• 1、 Jeon, Kyu Ok,Jun, Jung Ho,Yu, Ji Sook,Lee, Chang Kiu. "Infrared and Nuclear Magnetic Resonance Properties of Benzoyl Derivatives of Five-membered Monoheterocycles and Determination of Aromaticity Indices". . p. 763 - 771. Retrieved 2007/10/03.