2-Phenylquinoxaline

Base Information

• Chemical Name: 2-Phenylquinoxaline
• CAS No.: 5021-43-2
• Molecular Formula: C14H10N2
• Molecular Weight: 206.247
• Hs Code.: 2933990090
• Mol file: 5021-43-2.mol

Synonyms:Quinoxaline,2-phenyl;2-Phenyl-quinoxaline;Quinoxaline, 2-phenyl-;2-Phenyl-chinoxalin;

Chemical Property of 2-Phenylquinoxaline

Chemical Property:

• Vapor Pressure: 3.9E-05mmHg at 25°C
• Melting Point: 132-133 °C
• Boiling Point: 362.9°Cat760mmHg
• PKA: 0.57±0.30(Predicted)
• Flash Point: 158.1°C
• PSA: 25.78000
• Density: 1.176g/cm³
• LogP: 3.29680

Purity/Quality:

90%,98% ^*data from raw suppliers

2-PHENYL-QUINOXALINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenylquinoxaline

There total 165 articles about 2-Phenylquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-benzoyl-1,4-diphenylbut-2-ene-1,4-dione (102596-02-1) + 1,2-diamino-benzene (95-54-5) → 1,3-diphenylpropanedione (120-46-7,61346-73-4) + 2-phenylquinoxaline (5021-43-2)

Guidance literature:

With copper(II) acetate monohydrate; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Reagent/catalyst; Solvent; Temperature;

DOI:10.1002/chem.201403001

Reference yield: 93.0%

1-phenyl-2-hydroxyethanone (582-24-1) + 1,2-diamino-benzene (95-54-5) → benzoimidazole (51-17-2,79351-71-6) + 2-phenylquinoxaline (5021-43-2) + 2-phenyl-1H-benzoimidazole (716-79-0)

Guidance literature:

In diethylene glycol dimethyl ether; at 140 ℃; for 2h;

DOI:10.1016/j.jcat.2012.05.002

Reference yield: 90.0%

ethylbenzene (100-41-4,27536-89-6) + 1,2-diamino-benzene (95-54-5) → 2-phenylquinoxaline (5021-43-2)

Guidance literature:

ethylbenzene; With tert.-butylhydroperoxide; water; iodine; at 120 ℃; for 1h; Sealed tube;

1,2-diamino-benzene; With dimethyl sulfoxide; at 120 ℃; for 2h; Reagent/catalyst; Solvent; Temperature; Time; Sealed tube;

DOI:10.1039/c4ra08589b

upstream raw materials:

2,3-diethynylquinoxaline

N-nitrosoacetanilide

benzenediazohydroxide

dibenzoyl peroxide

Downstream raw materials:

1,1a,1b,2-tetrahydro-1a-phenyl-1,2-bis(phenylsulfonyl)bisazirino<1,2-a:2',1'-c>quinoxaline

1,2-bis(N,N-dimethylsulfamoyl)-1,1a,1b,2-tetrahydro-1a-phenylbisazirino<1,2-a:2',1'-c>quinoxaline

1,4-dihydro-1-(methoxycarbonyl)-2-phenylquinoxaline

1,4-dihydro-4-(methoxycarbonyl)-2-phenylquinoxaline

Refernces

• 1、 Dhakshinamoorthy, Amarajothi,Alvaro, Mercedes,Garcia, Hermenegildo. "Deactivation of Cu3(BTC)2 in the synthesis of 2-phenylquinoxaline". . p. 1600 - 1605. Retrieved 2015.
• 2、 Cui, Yan-Ying,Na, Jin-He,Guo, Meng-Meng,Huang, Jie-Ying,Chu, Xue-Qiang,Rao, Weidong,Shen, Zhi-Liang. "Cobalt-catalyzed cross-coupling of nitrogen-containing heterocyclic phosphonium salts with arylmagnesium reagents". supporting information. . Retrieved 2022/02/16.
• 3、 Chen, Yi,Miao, Jing,Tang, Lei,Wang, Bing,Wang, Cong,Wang, Haibo,Wang, Jianta,Wang, Xing,Zhang, Jiquan,Zhu, Gaofeng. "Direct C-2 arylation of quinoxaline with arylhydrazine salts as arylation reagents". supporting information. . Retrieved 2022/03/15.