3-Buten-1-ol, 4-phenyl-

Base Information

• Chemical Name: 3-Buten-1-ol, 4-phenyl-
• CAS No.: 770-36-5
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.205
• Nikkaji Number: J673.178C,J80.033C
• Mol file: 770-36-5.mol

Synonyms:(E)-4-phenylbut-3-en-1-ol;770-36-5;(E)-4-phenyl-but-3-en-1-ol;(3E)-4-Phenyl-3-buten-1-ol;3-Buten-1-ol, 4-phenyl-, (3E)-;3-Buten-1-ol, 4-phenyl-;4-PHENYLBUT-3-EN-1-OL;4-Phenyl-3-buten-1-ol;SCHEMBL1301627;SCHEMBL4171733;(E)-4-Phenyl-3-buten-1-ol;(3E)-4-Phenyl-3-buten-1-ol #;(3E)-4-PHENYLBUT-3-EN-1-OL;937-58-6;EN300-1637677

Chemical Property of 3-Buten-1-ol, 4-phenyl-

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 148.088815002
• Heavy Atom Count: 11
• Complexity: 112

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C=CCCO
• Isomeric SMILES: C1=CC=C(C=C1)/C=C/CCO

Technology Process of 3-Buten-1-ol, 4-phenyl-

There total 83 articles about 3-Buten-1-ol, 4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(E)-methyl 4-phenylbut-3-enoate (91083-82-8,24891-74-5,34541-74-7) → (3E)-4-phenyl-3-buten-1-ol (937-58-6,20047-19-2,770-36-5)

Guidance literature:

With lithium aluminium tetrahydride; 0 deg C, 1h then room temperature for 30 minutes;

DOI:10.1016/S0040-4020(01)88440-4

Reference yield: 96.0%

potassium (E)-trifluoro(4-phenylbut-3-en-1-yl)borate → (3E)-4-phenyl-3-buten-1-ol (937-58-6,20047-19-2,770-36-5)

Guidance literature:

With rose bengal; triethylamine; In ethanol; at 25 ℃; for 12h; Schlenk technique; Irradiation;

DOI:10.1021/acs.orglett.8b02095

Reference yield: 96.0%

4-phenyl-but-3-yn-1-ol (10229-11-5) → 4-phenylbuta-3-en-1-ol (770-36-5,20047-19-2,937-58-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 18h; Reflux; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201911742

upstream raw materials:

3-chloro-2-phenyl-tetrahydro-furan

oxirane

methyl magnesium iodide

bromostyrene

Downstream raw materials:

acetic acid-(4-phenyl-but-3-enyl ester)

Refernces

• 1、 Fang, Di,Zhang, Yidan,Chen, Yiyun. "Radical C(sp3)-H Heck-type Reaction of N-Alkoxybenzimidoyl Chlorides with Styrenes to Construct Alkenols". supporting information. p. 2050 - 2054. Retrieved 2022/03/17.
• 2、 Hoshino, Yoshihiko,Iwabuchi, Yoshiharu,Kuriyama, Yuse,Sasano, Yusuke,Uesugi, Shun-ichiro,Yamaichi, Aoto. "Highly Regioselective 5-endo-tet Cyclization of 3,4-Epoxy Amines into 3-Hydroxypyrrolidines Catalyzed by La(OTf)3". supporting information. p. 1961 - 1965. Retrieved 2021/01/04.