3-PHENYL-5-ISOXAZOLONE

Base Information

• Chemical Name: 3-PHENYL-5-ISOXAZOLONE
• CAS No.: 7713-79-3
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.16
• Mol file: 7713-79-3.mol

Synonyms:

Chemical Property of 3-PHENYL-5-ISOXAZOLONE

Chemical Property:

• PSA: 46.00000
• LogP: 1.63490

Purity/Quality:

97% ^*data from raw suppliers

3-PHENYL-5(2H)-ISOXAZOLONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-PHENYL-5-ISOXAZOLONE

There total 40 articles about 3-PHENYL-5-ISOXAZOLONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl β-anilinocinnamate (53256-22-7,124413-92-9,3556-76-1) → 3-phenyl-5-isoxazolone (7713-79-3)

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In methanol; for 3h; Heating;

DOI:10.1002/jhet.5570190657

Reference yield: 77.0%

ethyl 3-phenyl-3-(p-tolylamino)acrylate (85127-44-2) → 3-phenyl-5-isoxazolone (7713-79-3)

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In methanol; for 3h; Heating;

DOI:10.1002/jhet.5570190657

Reference yield:

ethyl 3-phenyl-3-(p-tolylamino)acrylate (85127-44-2) → 3-phenyl-5-isoxazolone (7713-79-3) + 3-hydroxy-5-phenylisoxazole (939-05-9)

Guidance literature:

With hydroxylamine hydrochloride; sodium methylate; In methanol; for 3h; Yield given; Heating;

DOI:10.1002/jhet.5570190657

upstream raw materials:

5-methoxy-3-phenylisoxazole

5-ethoxy-3-phenylisoxazole

3-phenyl-propynoic acid amide

ethanol

Downstream raw materials:

4-furfurylidene-3-phenyl-4H-isoxazol-5-one

3-phenyl-4-[2]thienylmethylene-4H-isoxazol-5-one

4-(3,5-dimethyl-1H-pyrazol-4-ylimino)-3-phenyl-4H-isoxazol-5-one

5-phenyl-3H-1,2-dithiole-3-thione

Refernces

• 1、 Kashima,Konno,Yoshiwara,Tajima. "Regioselective synthesis of 3-hydroxyisoxazoles and 5-isoxazolones from β-amino α,β-unsaturated esters". . p. 1535 - 1536. Retrieved 2007/10/02.