2-HYDROXYMETHYL-6-METHYLPYRAZINE

Base Information

• Chemical Name: 2-HYDROXYMETHYL-6-METHYLPYRAZINE
• CAS No.: 77164-93-3
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.142
• Hs Code.: 2933990090
• Mol file: 77164-93-3.mol

Synonyms:2-hydroxymethyl-6-methylpyrazine;(6-methyl-pyrazin-2-yl)-methanol;Pyrazinemethanol,6-methyl;6-hydroxymethyl-2-methylpyrazine;6-methylpyrazine-2-methanol;6-Methyl-2-pyrazinylmethanol;2-Hydroxymethyl-6-methyl-pyrazin;

Chemical Property of 2-HYDROXYMETHYL-6-METHYLPYRAZINE

Chemical Property:

• PSA: 46.01000
• LogP: 0.27730
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(6-Methylpyrazin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-HYDROXYMETHYL-6-METHYLPYRAZINE

There total 4 articles about 2-HYDROXYMETHYL-6-METHYLPYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-diaminopropan (78-90-0,10424-38-1) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 2,6-dimethylpyrazine (108-50-9) + 2-hydroxymethyl-6-methylpyrazine (77164-93-3) + 3,5-dimethylpiperazine (108-49-6)

Guidance literature:

With CuCr_imp; In water; at 375 ℃; under 760.051 Torr; Reagent/catalyst; Kinetics; Catalytic behavior; Flow reactor;

DOI:10.1039/c7cy00769h

Reference yield:

1,2-diaminopropan (78-90-0,10424-38-1) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 2,6-dimethylpyrazine (108-50-9) + 2-hydroxymethyl-6-methylpyrazine (77164-93-3)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 375 ℃; under 760.051 Torr; Reagent/catalyst; Kinetics; Catalytic behavior; Flow reactor;

DOI:10.1039/c7cy00769h

Reference yield:

1,2-diaminopropan (78-90-0,10424-38-1) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 2,5-dimethyl-pyrazine (123-32-0) + 2,6-dimethylpyrazine (108-50-9) + 2-hydroxymethyl-6-methylpyrazine (77164-93-3)

Guidance literature:

With water; at 380 ℃; Reagent/catalyst; regioselective reaction;

DOI:10.1016/j.cclet.2013.04.010

upstream raw materials:

1,2-diaminopropan

glycerol

Downstream raw materials:

6-methylpyrazine-2-carbaldehyde

Refernces

• 1、 Vankudoth, Krishna,Padmasri, A. Hari,Sarkari, Reema,Velisoju, Vijay Kumar,Gutta, Naresh,Sathu, Naveen Kumar,Rohita,Akula, Venugopal. "The role of Lewis acid-base pair sites in ZnO-ZnCr2O4 catalysts for cyclization: Via dehydrogenative condensation of crude glycerol and 1,2-propanediamine for the synthesis of 2,6-dimethylpyrazine". supporting information. p. 9875 - 9883. Retrieved 2017/09/18.