3-Butyne-1-thiol

Base Information

• Chemical Name: 3-Butyne-1-thiol
• CAS No.: 77213-87-7
• Molecular Formula: C4H6S
• Molecular Weight: 86.1576
• Mol file: 77213-87-7.mol

Synonyms:3-Butyne-1-thiol;butyne-3 thiol-1;3-butyn-1-thiol;4-mercapto-1-butyn;

Chemical Property of 3-Butyne-1-thiol

Chemical Property:

• PSA: 38.80000
• LogP: 0.93950

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Butyne-1-thiol

There total 6 articles about 3-Butyne-1-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C5H5NS → 3-butyne-1-thiol (77213-87-7)

Guidance literature:

With tetraphosphorus decasulfide; In toluene; for 1.2h; Reflux;

DOI:10.3762/bjoc.13.117

Reference yield: 72.0%

but-3-yn-1-yl carbamate (159492-70-3) → 3-butyne-1-thiol (77213-87-7)

Guidance literature:

With tetraphosphorus decasulfide; In toluene; for 2h; Reflux;

DOI:10.1055/s-0036-1589026

Reference yield: 65.0%

thioacetic acid S-but-3-ynyl ester (86220-08-8) → 3-butyne-1-thiol (77213-87-7)

Guidance literature:

With potassium carbonate;

DOI:10.1021/jo971787n

upstream raw materials:

2-But-3-ynyl-isothiourea; hydrobromide

thioacetic acid S-but-3-ynyl ester

but-3-yn-1-yl carbamate

Downstream raw materials:

2-decarboxy-16,17,18,19,20-pentanor-15-cyclohexyl-2,2,3,3,13,14-hexadehydro-6-thia-PGE₁ 11,15-bis(tert-butyldimethylsilyl ether)

Refernces

• 1、 Maurya, Chandra Kant,Gupta, Pradeep Kumar. "Phosphorus Pentasulfide Mediated Conversion of Primary Carbamates into Thiols". . p. 1649 - 1651. Retrieved 2017/08/11.
• 2、 Journet, Michel,Rouillard, Alain,Cai, Dongwei,Larsen, Robert D.. "Double Radical Cyclization/β-Fragmentation of Acyclic ω-Yne Vinyl Sulfides. Synthesis of 3-Vinyldihydrothiophene and Dihydrothiopyran Derivatives. A New Example of a 5-endo-trig Radical Cyclization". . p. 8630 - 8631. Retrieved 2007/10/03.