2-(3,5-DIBROMO-PHENYL)-[1,3]DIOXOLANE

Base Information

• Chemical Name: 2-(3,5-DIBROMO-PHENYL)-[1,3]DIOXOLANE
• CAS No.: 773094-77-2
• Molecular Formula: C9H8Br2O2
• Molecular Weight: 307.969
• Mol file: 773094-77-2.mol

Synonyms:2-(3,5-Dibromo-phenyl)-[1,3]dioxolane;

Chemical Property of 2-(3,5-DIBROMO-PHENYL)-[1,3]DIOXOLANE

Chemical Property:

• PSA: 18.46000
• LogP: 3.25700

Purity/Quality:

99% ^*data from raw suppliers

2-(3,5-Dibromophenyl)-1,3-dioxolane >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,5-DIBROMO-PHENYL)-[1,3]DIOXOLANE

There total 1 articles about 2-(3,5-DIBROMO-PHENYL)-[1,3]DIOXOLANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,5-dibromobenzaldehyde (56990-02-4) + ethylene glycol (107-21-1) → 2-(3,5-dibromophenyl)-1,3-dioxolane (773094-77-2)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 1h; Heating / reflux;

Reference yield: 100.0%

2-(3,5-dibromophenyl)-1,3-dioxolane (773094-77-2) → 3-bromo-5-[1,3]dioxolan-2-yl-phenol (909854-23-5)

Guidance literature:

2-(3,5-dibromophenyl)-1,3-dioxolane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

With Trimethyl borate; In tetrahydrofuran; hexane; at 0 ℃; for 4h;

With dihydrogen peroxide; acetic acid; In tetrahydrofuran; hexane; water; at 0 - 20 ℃; for 4.5h;

Reference yield: 86.8%

2-(3,5-dibromophenyl)-1,3-dioxolane (773094-77-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → C10H9BrO3

Guidance literature:

2-(3,5-dibromophenyl)-1,3-dioxolane; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;

upstream raw materials:

3,5-dibromobenzaldehyde

ethylene glycol

Downstream raw materials:

5-[1,3]dioxolan-2-yl-isophthalic acid dibutyl ester

2-(3-bromo-5-vinyl-phenyl)-[1,3]dioxolane

3-[1,3]dioxolan-2-yl-5-vinyl-phenol

3-(tetrahydro-pyran-4-yloxy)-5-vinyl-benzaldehyde

Refernces

• 1、 -. "BETA AMINO ACID DERIVATIVES AS INTEGRIN ANTAGONISTS". Paragraph 254. . Retrieved 2014/02/15.
• 2、 Zbinden, Katrin Groebke,Obst-Sander, Ulrike,Hilpert, Kurt,Kuehne, Holger,Banner, David W.,Boehm, Hans-Joachim,Stahl, Martin,Ackermann, Jean,Alig, Leo,Weber, Lutz,Wessel, Hans Peter,Riederer, Markus A.,Tschopp, Thomas B.,Lave, Thierry. "Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors". . p. 5344 - 5352. Retrieved 2007/10/03.