Benzenamine, 4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)-

Base Information

• Chemical Name: Benzenamine, 4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)-
• CAS No.: 774238-52-7
• Molecular Formula: C13H15N3
• Molecular Weight: 213.282
• Hs Code.: 2933990090
• Mol file: 774238-52-7.mol

Synonyms:

Chemical Property of Benzenamine, 4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)-

Chemical Property:

• PSA: 43.84000
• LogP: 3.04980

Purity/Quality:

99% ^*data from raw suppliers

4-(5H,6H,7H,8H-Imidazo[1,2-a]pyridin-2-yl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(5H,6H,7H,8H-Imidazo[1,2-a]pyridin-2-yl)aniline

Technology Process of Benzenamine, 4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)-

There total 4 articles about Benzenamine, 4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-nitrophenyl)imidazo[1,2-a]pyridine (3323-26-0) → 2-(4-aminophenyl)imidazo<1,2-a>pyridine (139705-74-1) + 4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenylamine (774238-52-7)

Guidance literature:

With hydrogen; 5% palladium over charcoal; In tetrahydrofuran; methanol; for 5h;

Reference yield:

2-(4-nitrophenyl)imidazo[1,2-a]pyridine (3323-26-0) → 4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenylamine (774238-52-7)

Guidance literature:

With hydrogen; Ra-Ni; for 3h; under 2280 - 3040 Torr;

DOI:10.1002/jhet.5570250119

Reference yield:

2-aminopyridine (504-29-0) → 4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenylamine (774238-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 2)HBr / 1) acetone, reflux, 3 h, 2) methanol, reflux, 60 min

2: H₂ / Ra-Ni / 3 h / 2280 - 3040 Torr

With hydrogen bromide; hydrogen; Ra-Ni;

DOI:10.1002/jhet.5570250119

upstream raw materials:

2-(4-nitrophenyl)imidazo[1,2-a]pyridine

2-aminopyridine

4-Nitrophenacyl bromide

Refernces

• 1、 Sundberg,Dahlhausen,Manikumar,Mavunkel,Biswas,Srinivasan,King Jr.,Waid. "Preparation of 2-aryl and 2-aryloxymethyl imidazo[1,2-a]pyridines and related compounds". . p. 129 - 137. Retrieved 2007/10/02.