3-NITRO-PHTHALIC ACID 2-METHYL ESTER

Base Information

• Chemical Name: 3-NITRO-PHTHALIC ACID 2-METHYL ESTER
• CAS No.: 6744-85-0
• Molecular Formula: C9H7NO6
• Molecular Weight: 225.158
• Hs Code.: 2918990090
• Mol file: 6744-85-0.mol

Synonyms:3-nitro-phthalic acid-2-methyl ester;3-Nitro-phthalsaeure-2-methylester;2-(methoxycarbonyl)-3-nitrobenzoic acid;2-methyl 3-nitrophthalate;

Chemical Property of 3-NITRO-PHTHALIC ACID 2-METHYL ESTER

Chemical Property:

• Vapor Pressure: 8.34E-07mmHg at 25°C
• Melting Point: 144-153 °C
• Boiling Point: 390.7°Cat760mmHg
• PKA: 2.38±0.20(Predicted)
• Flash Point: 190.1°C
• PSA: 109.42000
• Density: 1.484g/cm³
• LogP: 1.60280
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

3-Nitro-phthalicAcid2-methylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-NITRO-PHTHALIC ACID 2-METHYL ESTER

There total 9 articles about 3-NITRO-PHTHALIC ACID 2-METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methanol (67-56-1) + 3-nitrophthalic acid anhydride (641-70-3) → 2-(methoxycarbonyl)-3-nitrobenzoic acid (6744-85-0)

Guidance literature:

for 7h; Heating;

DOI:10.1002/prac.19933350104

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 3-nitrophthalic acid (603-11-2) → 2-(methoxycarbonyl)-3-nitrobenzoic acid (6744-85-0) + dimethyl 3-nitrophthalate (13365-26-9)

Guidance literature:

With diethyl ether;

Reference yield:

3-nitrophthalic acid anhydride (641-70-3) → 2-(methoxycarbonyl)-3-nitrobenzoic acid (6744-85-0)

Guidance literature:

In ethanol;

upstream raw materials:

diazomethane

3-nitrophthalic acid

methanol

3-nitrophthalic acid anhydride

Downstream raw materials:

dimethyl 3-nitrophthalate

7-nitro-3H-isobenzofuran-1-one

3-amino-2-(methoxycarbonyl)benzoic acid

methyl 2-carboxy-3-nitrobenzoate

Refernces

• 1、 Funk, Petr,Motyka, Kamil,D?ubák, Petr,Znojek, Pawel,Gurská, Soňa,Kusz, Joachim,McMaster, Claire,Hajdúch, Marián,Soural, Miroslav. "Preparation of 2-phenyl-3-hydroxyquinoline-4(1H)-one-5-carboxamides as potential anticancer and fluorescence agents". . p. 48861 - 48867. Retrieved 2015/06/16.
• 2、 -. "Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use". Page/Page column 22; 63. . Retrieved 2010/02/11.