4-Hydroxy-N-methyl-N-isopropyltryptamine

Base Information

• Chemical Name: 4-Hydroxy-N-methyl-N-isopropyltryptamine
• CAS No.: 77872-43-6
• Molecular Formula: C₁₄H₂₀N₂O
• Molecular Weight: 232.326
• Hs Code.: 2933990090
• UNII: 4GAJ9OJ8YZ
• DSSTox Substance ID: DTXSID30228492
• Wikipedia: 4-HO-MiPT
• Wikidata: Q162772
• ChEMBL ID: CHEMBL171419
• Mol file: 77872-43-6.mol

Synonyms:77872-43-6;4-HO-MiPT;4-Hydroxy-N-methyl-N-isopropyltryptamine;4-HYDROXY-N-ISOPROPYL-N-METHYLTRYPTAMINE;UNII-4GAJ9OJ8YZ;4GAJ9OJ8YZ;4-hydroxy MIPT;3-[2-[methyl(propan-2-yl)amino]ethyl]-1H-indol-4-ol;1H-Indol-4-ol, 3-[2-[methyl(1-methylethyl)amino]ethyl]-;HATS;MIPROCIN;4-HYDROXY-MIPT;3-(2-(Isopropyl(methyl)amino)ethyl)-1H-indol-4-ol;CHEMBL171419;SCHEMBL20970976;3-[2-[Methyl(1-methylethyl)amino]ethyl]-1H-indol-4-ol;DTXSID30228492;RXKGHZCQFXXWFQ-UHFFFAOYSA-N;EN-0008;PD020233;FT-0669668;Q162772

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Chemical Property of 4-Hydroxy-N-methyl-N-isopropyltryptamine

Chemical Property:

• Boiling Point: 407.36 °C at 760 mmHg
• PKA: 10.08±0.40(Predicted)
• Flash Point: 200.164 °C
• PSA: 37.19000
• Density: 1.124 g/cm³
• LogP: 2.22930
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 232.157563266
• Heavy Atom Count: 17
• Complexity: 244

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)N(C)CCC1=CNC2=C1C(=CC=C2)O
• Description: 4-HO-MiPT (miprocin, 4-hydroxy-N-methyl-N-isopropyltryptamine) is a synthetic substituted aromatic compound and a lesser-known psychedelic tryptamine. It is thought to be a serotonergic psychedelic, similar to magic mushrooms, LSD and mescaline. Its molecular structure and pharmacological effects somewhat resemble those of the tryptamine psilocin, which is the primary psychoactive chemical in magic mushrooms.
• Uses: 4-hydroxy MiPT is a synthetic tryptamine derivative that is part of the class of drugs known as serotonergic psychedelics, which includes psychoactive mushrooms, LSD, and mescaline. Its effects and molecular structure resemble that of the tryptamine psilocin. This product is intended for forensic and research applications.[Cayman Chemical]

Technology Process of 4-Hydroxy-N-methyl-N-isopropyltryptamine

There total 2 articles about 4-Hydroxy-N-methyl-N-isopropyltryptamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Acetic acid 3-(isopropyl-methyl-aminooxalyl)-1H-indol-4-yl ester (77872-28-7) → 4-hydroxy-N-methyl-N-isopropyltryptamine (77872-43-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.25h; Heating;

DOI:10.1002/jhet.5570180131

Reference yield:

acetic acid 1H-indol-4-yl ester (5585-96-6) → 4-hydroxy-N-methyl-N-isopropyltryptamine (77872-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) diethylether, 4 deg C, 18 h 2) diethylether

2: 74 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1002/jhet.5570180131

upstream raw materials:

Acetic acid 3-(isopropyl-methyl-aminooxalyl)-1H-indol-4-yl ester

acetic acid 1H-indol-4-yl ester

Refernces