Benzamide, 4-(chloromethyl)- (9CI)

Base Information

• Chemical Name: Benzamide, 4-(chloromethyl)- (9CI)
• CAS No.: 84545-14-2
• Molecular Formula: C8H8 Cl N O
• Molecular Weight: 169.611
• Hs Code.: 2924299090
• Mol file: 84545-14-2.mol

Synonyms:4-(Chloromethyl)benzamide

Chemical Property of Benzamide, 4-(chloromethyl)- (9CI)

Chemical Property:

• Vapor Pressure: 0.000202mmHg at 25°C
• Boiling Point: 327.4°C at 760 mmHg
• Flash Point: 151.8°C
• PSA: 43.09000
• Density: 1.248g/cm³
• LogP: 2.22460
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Chloromethyl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzamide, 4-(chloromethyl)- (9CI)

There total 3 articles about Benzamide, 4-(chloromethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

p-(chloromethyl)benzoyl chloride (876-08-4) → tert-butyl 4-(chloromethyl)benzamide (84545-14-2)

Guidance literature:

With ammonia; water; In toluene; at 0 - 20 ℃; for 2h;

Reference yield: 47.0%

4-methylthiazol-2-ylamine (1603-91-4) + p-(chloromethyl)benzoic acid (1642-81-5) → tert-butyl 4-(chloromethyl)benzamide (84545-14-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.ejmech.2018.09.003

Reference yield:

2-aminoacetophenone (551-93-9) + 2-nitro-benzaldehyde (552-89-6) → tert-butyl 4-(chloromethyl)benzamide (84545-14-2)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; ethylene glycol; toluene;

upstream raw materials:

p-(chloromethyl)benzoyl chloride

2-aminoacetophenone

2-nitro-benzaldehyde

4-methylthiazol-2-ylamine

Downstream raw materials:

p-(chloromethyl)benzoic acid

4-dimethylaminomethyl-benzoic acid amide

5-(4-chloromethyl-phenyl)-[1,3,4]oxathiazol-2-one

4-((4-methylpiperazin-1-yl)methyl)benzamide

Refernces

• 1、 Szakács, Zoltán,Béni, Szabolcs,Varga, Zoltán,?rfi, László,Kéri, Gy?rgy,Noszál, Béla. "Acid-base profiling of imatinib (Gleevec) and its fragments". . p. 249 - 255. Retrieved 2007/10/03.
• 2、 -. "Nonpeptide agonists and antagonists of vasopressin receptors". . . Retrieved 2008/06/13.