Technology Process of 2(1H)-Naphthalenone,
3,4-dihydro-1-hydroxy-7-methoxy-1,6-dimethyl-4-(1-methylethyl)-
There total 18 articles about 2(1H)-Naphthalenone,
3,4-dihydro-1-hydroxy-7-methoxy-1,6-dimethyl-4-(1-methylethyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at -78 ℃;
for 0.333333h;
1) -78 deg C, 20 min, 2) -70 deg C, 7 min;
DOI:10.1021/jo00175a007
- Guidance literature:
-
With
osmium(VIII) oxide; 4-methylmorpholine N-oxide;
N-benzyl-trimethylammonium hydroxide;
In
water; tert-butyl alcohol;
at 10 ℃;
for 1.66667h;
DOI:10.1021/jo00175a007
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 97.3 percent / polyphosphoric acid / 87 °C / 1) 1 min, 2) 30 min
2: diethyl ether / 1) RT, 20 min, 2) reflux, 30 min
3: 1.31 g / 4 N HCl / benzene; H2O / 0.17 h
4: 94 percent / N-methylmorpholine N-oxide hydrate, OsO4 / acetone; H2O / 48 h / 23 °C
5: 97 percent / p-TsOH monohydrate / benzene
6: hexamethyldisilazane / CH2Cl2 / 1.) -10 deg C, 1 h, 2.) room temperature
7: 80 mg / N-methylmorpholine N-oxide hydrate, OsO4 / Triton B / 2-methyl-propan-2-ol; H2O / 1.67 h / 10 °C
With
hydrogenchloride; osmium(VIII) oxide; PPA; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; 1,1,1,3,3,3-hexamethyl-disilazane;
N-benzyl-trimethylammonium hydroxide;
In
diethyl ether; dichloromethane; water; acetone; tert-butyl alcohol; benzene;
DOI:10.1021/jo00175a007