Propanamide, 2-[[[4-(dimethylamino)phenyl]methylene]amino]-N-[4-[(4-nitrophenyl)sulf onyl]phenyl]-

Base Information

• Chemical Name: Propanamide, 2-[[[4-(dimethylamino)phenyl]methylene]amino]-N-[4-[(4-nitrophenyl)sulf onyl]phenyl]-
• CAS No.: 78428-72-5
• Molecular Formula: C₂₄H₂₄N₄O₅S
• Molecular Weight: 480.544
• Mol file: 78428-72-5.mol

Synonyms:

Chemical Property of Propanamide, 2-[[[4-(dimethylamino)phenyl]methylene]amino]-N-[4-[(4-nitrophenyl)sulf onyl]phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanamide, 2-[[[4-(dimethylamino)phenyl]methylene]amino]-N-[4-[(4-nitrophenyl)sulf onyl]phenyl]-

There total 4 articles about Propanamide, 2-[[[4-(dimethylamino)phenyl]methylene]amino]-N-[4-[(4-nitrophenyl)sulf onyl]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2-{[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(4-nitro-phenylsulfanyl)-phenyl]-propionamide (78428-38-3) → 2-{[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(4-nitro-benzenesulfonyl)-phenyl]-propionamide (78428-72-5)

Guidance literature:

With dihydrogen peroxide; In acetic acid; Ambient temperature;

Reference yield:

4-amino-4'-nitrodiphenyl sulfide (101-59-7) → 2-{[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(4-nitro-benzenesulfonyl)-phenyl]-propionamide (78428-72-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / triethylamine / dioxane / Ambient temperature

2: 1) hydrazine hydrate, 2) aq. HCl / 1) ethanol, 1h, reflux, 2a) 50 deg C, 10 min, 2b) 30 min, room temp.

3: 89 percent / piperidine / ethanol / Heating

4: 47 percent / 30percent hydrogen peroxide / acetic acid / Ambient temperature

With piperidine; hydrogenchloride; dihydrogen peroxide; hydrazine hydrate; triethylamine; In 1,4-dioxane; ethanol; acetic acid;

Reference yield:

2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-[4-(4-nitro-phenylsulfanyl)-phenyl]-propionamide (78428-14-5) → 2-{[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(4-nitro-benzenesulfonyl)-phenyl]-propionamide (78428-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) hydrazine hydrate, 2) aq. HCl / 1) ethanol, 1h, reflux, 2a) 50 deg C, 10 min, 2b) 30 min, room temp.

2: 89 percent / piperidine / ethanol / Heating

3: 47 percent / 30percent hydrogen peroxide / acetic acid / Ambient temperature

With piperidine; hydrogenchloride; dihydrogen peroxide; hydrazine hydrate; In ethanol; acetic acid;

upstream raw materials:

2-{[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(4-nitro-phenylsulfanyl)-phenyl]-propionamide

4-amino-4'-nitrodiphenyl sulfide

2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-[4-(4-nitro-phenylsulfanyl)-phenyl]-propionamide

2-Amino-N-[4-(4-nitro-phenylsulfanyl)-phenyl]-propionamide; hydrochloride

Refernces