Benzonitrile, 2-(2-methoxyphenoxy)-

Base Information

• Chemical Name: Benzonitrile, 2-(2-methoxyphenoxy)-
• CAS No.: 79365-16-5
• Molecular Formula: C14H11NO2
• Molecular Weight: 225.247
• Mol file: 79365-16-5.mol

Synonyms:

Chemical Property of Benzonitrile, 2-(2-methoxyphenoxy)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzonitrile, 2-(2-methoxyphenoxy)-

There total 2 articles about Benzonitrile, 2-(2-methoxyphenoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-fluorobenzonitrile (394-47-8) + 2-methoxy-phenol (90-05-1) → 2-(2'-methoxyphenoxy)benzonitrile (79365-16-5)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; for 0.0833333h; Heating; microwave irradiation;

DOI:10.1021/ol0346436 DOI:10.1055/s-2005-865321

Reference yield: 26.0%

2-Methoxyphenylboronic acid (5720-06-9) + o-nitrobenzonitrile (612-24-8) → 2-(2'-methoxyphenoxy)benzonitrile (79365-16-5)

Guidance literature:

With C₂₉H₂₆FeN₃Pd⁽¹⁺⁾*Cl^(1-); oxygen; caesium carbonate; In 1,4-dioxane; dimethyl sulfoxide; at 100 ℃; for 24h;

DOI:10.1016/j.tet.2013.05.112

Reference yield:

2-(2'-methoxyphenoxy)benzonitrile (79365-16-5) → salicylonitrile (611-20-1) + 2-methoxy-phenol (90-05-1)

Guidance literature:

With uranyl(VI) nitrate monohydrate; water; trichloroacetic acid; at -78 - 25 ℃; for 72h; Irradiation; Inert atmosphere;

upstream raw materials:

2-fluorobenzonitrile

2-methoxy-phenol

2-Methoxyphenylboronic acid

o-nitrobenzonitrile

Downstream raw materials:

2-methoxyphenyl 2-hydroxybenzoate

2-(2-hydroxy-phenoxy)-benzoic acid

2-(2-hydroxy-phenoxy)-benzoic acid methyl ester

Guaiaspir

Refernces

• 1、 Chang, Xihao,Zhang, Qinglin,Guo, Chang. "Electrochemical Reductive Smiles Rearrangement for C-N Bond Formation". supporting information. p. 10 - 13. Retrieved 2019/01/04.
• 2、 Peng, Dongpo,Yu, Ajuan,Wang, Hailei,Wu, Yangjie,Chang, Junbiao. "A 2,2′-bipyridine-palladacycle catalyzed the coupling of arylboronic acids with nitroarenes". . p. 6884 - 6889. Retrieved 2013/07/26.