1-(4-Methylphenyl)-2-(methylphenylamino)ethanone

Base Information

• Chemical Name: 1-(4-Methylphenyl)-2-(methylphenylamino)ethanone
• CAS No.: 79409-00-0
• Molecular Formula: C16H17NO
• Molecular Weight: 239.317
• DSSTox Substance ID: DTXSID101236992
• Mol file: 79409-00-0.mol

Synonyms:1-(4-Methylphenyl)-2-(methylphenylamino)ethanone;79409-00-0;SCHEMBL11671631;DTXSID101236992;AKOS009049553

Chemical Property of 1-(4-Methylphenyl)-2-(methylphenylamino)ethanone

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 239.131014166
• Heavy Atom Count: 18
• Complexity: 262

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=O)CN(C)C2=CC=CC=C2

Technology Process of 1-(4-Methylphenyl)-2-(methylphenylamino)ethanone

There total 6 articles about 1-(4-Methylphenyl)-2-(methylphenylamino)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-(bromoacetyl)toluene (619-41-0) + N-methylaniline (100-61-8) → 2-(methyl(phenyl)amino)-1-(p-tolyl)ethan-1-one (79409-00-0)

Guidance literature:

With potassium carbonate; In acetonitrile; Inert atmosphere; Reflux;

DOI:10.1039/c6cc02027e

Reference yield: 86.0%

2-(Diphenyl-phosphinoyl)-2-(methyl-phenyl-amino)-1-p-tolyl-ethanol (79409-09-9) → 2-(methyl(phenyl)amino)-1-(p-tolyl)ethan-1-one (79409-00-0)

Guidance literature:

In ethylene glycol; at 140 - 150 ℃; for 3h;

DOI:10.1016/S0040-4039(01)90556-8

Reference yield: 60.0%

1-(((dimethyl(oxo)- λ6-sulfanylidene)methyl)sulfonyl)-4-methylbenzene + N-methylaniline (100-61-8) → 2-(methyl(phenyl)amino)-1-(p-tolyl)ethan-1-one (79409-00-0)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; In water; for 24h; Schlenk technique; Heating; Green chemistry;

DOI:10.1002/ejoc.202000716

upstream raw materials:

4-(bromoacetyl)toluene

N-methylaniline

2-(Diphenyl-phosphinoyl)-2-(methyl-phenyl-amino)-1-p-tolyl-ethanol

1-ethenyl-4-methylbenzene

Downstream raw materials:

2-(4-methylphenyl)-1H-indole

1-methyl-2-(4-methylphenyl)indole

1-(morpholin-4-yl)-2-(p-tolyl)ethane-1,2-dione

3-hydroxy-1-methyl-3-p-tolylindolin-2-one

Refernces

• 1、 Xu, Yingying,Huang, Xin,Lv, Guanghui,Lai, Ruizhi,Lv, Songyang,Li, Jianglian,Hai, Li,Wu, Yong. "Iridium-Catalyzed Carbenoid Insertion of Sulfoxonium Ylides for Synthesis of Quinoxalines and β-Keto Thioethers in Water". supporting information. p. 4635 - 4638. Retrieved 2020/07/04.
• 2、 Shinde, Mahesh H.,Kshirsagar, Umesh A.. "N-Bromosuccinimide promoted and base switchable one pot synthesis of α-imido and α-amino ketones from styrenes". supporting information. p. 858 - 861. Retrieved 2016/01/15.