2-phenylpropanamide

Base Information

• Chemical Name: 2-phenylpropanamide
• CAS No.: 1125-70-8
• Molecular Formula: C9H11 N O
• Molecular Weight: 149.192
• Mol file: 1125-70-8.mol

Synonyms:Hydratropamide(6CI,7CI,8CI); (RS)-2-Phenylpropionamide; (?à)-2-Phenylpropionamide; (?à)-Hydratropamide; (?à)-a-Methylbenzeneacetamide; 2-Phenylpropionamide; NSC 11140; NSC 59889; a-Phenylpropionamide

Chemical Property of 2-phenylpropanamide

Chemical Property:

• Vapor Pressure: 0.000876mmHg at 25°C
• Boiling Point: 304.4°Cat760mmHg
• Flash Point: 137.9°C
• PSA: 43.09000
• Density: 1.063g/cm³
• LogP: 1.97570

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-phenylpropanamide

There total 43 articles about 2-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Phenylpropanal (34713-70-7) → 2-phenylpropanamide (1125-70-8)

Guidance literature:

With hydroxylamine; copper diacetate; In water; at 110 ℃; for 48h;

DOI:10.1016/j.tet.2012.03.085

Reference yield: 99.0%

1-phenylethyl cyanide (1823-91-2) → 2-phenylpropanamide (1125-70-8)

Guidance literature:

With dichloro( 1,5-cyclooctadiene)platinum(ll); 4,5-dihydro-3H-dinaphtho[2,1-c:1',2'-e]phosphepine-4-oxide; water; silver nitrate; In tert-Amyl alcohol; at 80 ℃; for 1h; Reagent/catalyst; Time; chemoselective reaction; Catalytic behavior;

DOI:10.1039/c5cy00627a

Reference yield: 97.0%

C14H19N3O (1309977-10-3) → 2-phenylpropanamide (1125-70-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

DOI:10.1016/j.tetlet.2011.04.042

upstream raw materials:

methanol

methyl hydratropimidate hydrochloride

2-phenylacrolein

1-methyl-1-phenylethyl alcohol

Downstream raw materials:

1,2-diphenylpropan-1-one

1-phenylethyl cyanide

3-phenyl-butan-2-one

1,2-diphenyl-propan-1-one oxime

Refernces

• 1、 Kaiser,Hauser. "-". . p. 3873. Retrieved 1966.
• 2、 Han, Buxing,Ke, Zhengang,Li, Ruipeng,Liu, Zhimin,Tang, Minhao,Wang, Yuepeng,Zeng, Wei,Zhang, Fengtao,Zhao, Yanfei. "A CO2-mediated base catalysis approach for the hydration of triple bonds in ionic liquids". supporting information. p. 9870 - 9875. Retrieved 2021/12/27.
• 3、 Vasilopoulos, Aristidis,Krska, Shane W.,Stahl, Shannon S.. "C(sp3)-H methylation enabled by peroxide photosensitization and Ni-mediated radical coupling". . p. 398 - 403. Retrieved 2021/05/06.