Technology Process of 1,3-Benzenedicarboxylic acid,
5-[[4-[(4-ethynylphenyl)ethynyl]phenyl]ethynyl]-, dimethyl ester
There total 3 articles about 1,3-Benzenedicarboxylic acid,
5-[[4-[(4-ethynylphenyl)ethynyl]phenyl]ethynyl]-, dimethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
DOI:10.1021/jp047454t
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 9-methoxy-9-borabicyclo[3.3.1]nonane / tetrahydrofuran; hexane / 2 h / -78 °C
1.3: 60 percent / Pd(PPh3)4 / tetrahydrofuran; hexane / Heating
2.1: 90 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 20 °C
With
tetrabutyl ammonium fluoride; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane;
DOI:10.1021/jp047454t
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 74 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 20 °C
2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 9-methoxy-9-borabicyclo[3.3.1]nonane / tetrahydrofuran; hexane / 2 h / -78 °C
2.3: 60 percent / Pd(PPh3)4 / tetrahydrofuran; hexane / Heating
3.1: 90 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 20 °C
With
tetrabutyl ammonium fluoride; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane;
DOI:10.1021/jp047454t