5-Amino-2-methoxy-4-picoline

Base Information

• Chemical Name: 5-Amino-2-methoxy-4-picoline
• CAS No.: 6635-91-2
• Molecular Formula: C7H10N2O
• Molecular Weight: 138.169
• Hs Code.: 2933399090
• European Community (EC) Number: 674-931-1
• NSC Number: 52458
• DSSTox Substance ID: DTXSID60287774
• Nikkaji Number: J1.408.457F
• Wikidata: Q72438739
• Mol file: 6635-91-2.mol

Synonyms:6635-91-2;5-Amino-2-methoxy-4-picoline;6-methoxy-4-methylpyridin-3-amine;5-amino-2-methoxy-4-methylpyridine;6-methoxy-4-methyl-pyridin-3-ylamine;2-Methoxy-4-methyl-5-pyridinamine;MFCD08277274;NSC52458;5-Amino-2-methoxy-4-methyl pyridine;SCHEMBL3668216;DTXSID60287774;AMY36607;NSC 52458;NSC-52458;6-Methoxy-4-methyl-3-pyridinamine #;AKOS006345789;AB44888;CS-W005237;GS-5049;4-methyl-6-(methyloxy)-3-pyridinamine;AC-24959;SY041329;5-amino-2-methoxy-4-picoline, AldrichCPR;A8953;FT-0659376;I10132;EN300-1295909;J-516697

Chemical Property of 5-Amino-2-methoxy-4-picoline

Chemical Property:

• Vapor Pressure: 0.00373mmHg at 25°C
• Melting Point: 157-161 °C
• Refractive Index: 1.553
• Boiling Point: 280.674 °C at 760 mmHg
• Flash Point: 123.548 °C
• PSA: 48.14000
• Density: 1.103 g/cm³
• LogP: 1.56200
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 138.079312947
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

99% ^*data from raw suppliers

N-(2,2-Dimethoxyethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC=C1N)OC

Technology Process of 5-Amino-2-methoxy-4-picoline

There total 2 articles about 5-Amino-2-methoxy-4-picoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methoxy-4-methyl-5-nitropyridine (6635-90-1) → 4-methyl-6-(methyloxy)-3-pyridinamine (6635-91-2)

Guidance literature:

With ethanol; iron; acetic acid;

Reference yield:

tin(II)chloride dihydrate + 2-Methoxy-4-methyl-5-nitropyridine (6635-90-1) → 4-methyl-6-(methyloxy)-3-pyridinamine (6635-91-2)

Guidance literature:

With hydrogenchloride; In acetic acid;

Reference yield: 100.0%

4-methyl-6-(methyloxy)-3-pyridinamine (6635-91-2) + 2-nitrophenyl bromide (577-19-5) → 6-methoxy-4-methyl-N-(2-nitrophenyl)pyridin-3-amine

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium tert-pentoxide; XPhos; In 1,4-dioxane; at 110 ℃;

upstream raw materials:

2-Methoxy-4-methyl-5-nitropyridine

Downstream raw materials:

N-(6-methoxy-4-methylpyridin-3-yl)acetamide

5-methoxy-1H-pyrazolo[3,4-c]pyridine

2-bromo-6-methoxy-4-methylpyridin-3-amine

Refernces

• 1、 -. "5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection". . . Retrieved 2008/06/13.