2,3-Dichloro-4-Methylaniline

Base Information

• Chemical Name: 2,3-Dichloro-4-Methylaniline
• CAS No.: 80026-12-6
• Molecular Formula: C7H7Cl2N
• Molecular Weight: 176.045
• Hs Code.: 2921430090
• Mol file: 80026-12-6.mol

Synonyms:2,3-Dichlor-4-methyl-anilin;2.3-Dichlor-p-toluidin;2.3-Dichlor-4-amino-toluol;

Chemical Property of 2,3-Dichloro-4-Methylaniline

Chemical Property:

• PSA: 26.02000
• LogP: 3.46520

Purity/Quality:

99% ^*data from raw suppliers

2,3-dichloro-4-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Dichloro-4-Methylaniline

There total 4 articles about 2,3-Dichloro-4-Methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

3-chloro-p-toluidine (95-74-9,827571-80-2) → 2,3-dichloro-4-methylaniline (80026-12-6)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;

Reference yield:

acetic acid-(2,3-dichloro-4-methyl-anilide) (136403-10-6) → 2,3-dichloro-4-methylaniline (80026-12-6)

Guidance literature:

With sulfuric acid;

Reference yield:

N-(3-chloro-4-methylphenyl)acetamide (7149-79-3) → 2,3-dichloro-4-methylaniline (80026-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diluted acetic acid; chlorine / 0 - 5 °C

2: sulfuric acid

With sulfuric acid; chlorine; acetic acid;

upstream raw materials:

acetic acid-(2,3-dichloro-4-methyl-anilide)

N-(3-chloro-4-methylphenyl)acetamide

3-chloro-p-toluidine

Downstream raw materials:

2,3,4-trichlorobenzoic acid

2,3,4-trichlorotoluene

2-(2,3-Dichloro-4-methyl-phenylamino)-9,10-dimethoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one

Refernces

• 1、 -. "SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH". Paragraph 0362. . Retrieved 2016/05/02.