1-Propanone, 3-(4-methoxyphenyl)-1-phenyl-3-(phenylamino)-

Base Information

• Chemical Name: 1-Propanone, 3-(4-methoxyphenyl)-1-phenyl-3-(phenylamino)-
• CAS No.: 802-48-2
• Molecular Formula: C22H21NO2
• Molecular Weight: 331.414
• DSSTox Substance ID: DTXSID70387895
• Nikkaji Number: J405.781C
• Mol file: 802-48-2.mol

Synonyms:1-Propanone, 3-(4-methoxyphenyl)-1-phenyl-3-(phenylamino)-;802-48-2;3-anilino-3-(4-methoxyphenyl)-1-phenylpropan-1-one;DTXSID70387895;AKOS032969070;beta-(4-Methoxyphenyl)-beta-anilinopropiophenone;3-(4-METHOXYPHENYL)-1-PHENYL-3-(PHENYLAMINO)PROPAN-1-ONE

Chemical Property of 1-Propanone, 3-(4-methoxyphenyl)-1-phenyl-3-(phenylamino)-

Chemical Property:

• XLogP3: 5.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 331.157228913
• Heavy Atom Count: 25
• Complexity: 391

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(CC(=O)C2=CC=CC=C2)NC3=CC=CC=C3

Technology Process of 1-Propanone, 3-(4-methoxyphenyl)-1-phenyl-3-(phenylamino)-

There total 7 articles about 1-Propanone, 3-(4-methoxyphenyl)-1-phenyl-3-(phenylamino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-styrenyloxytrimethylsilane (13735-81-4) + 4-methoxy-benzaldehyde (123-11-5) + aniline (62-53-3) → 3-(4-methoxyphenyl)-1-phenyl-3-(N-phenylamino)propan-1-one (802-48-2)

Guidance literature:

With iodine; In methanol; at 20 ℃; for 0.166667h;

DOI:10.1055/s-2005-868487

Reference yield: 99.0%

4-methoxy-benzaldehyde (123-11-5) + aniline (62-53-3) + acetophenone (98-86-2) → 3-(4-methoxyphenyl)-1-phenyl-3-(N-phenylamino)propan-1-one (802-48-2)

Guidance literature:

With Sn incorporated mesoporous silica MCM-41 supported ionic liquid consisting of SO₃H and TiCl₅; In ethanol; at 20 ℃; for 2h;

DOI:10.1039/c7nj02541f

Reference yield: 97.0%

trans-4-methoxychalcone (22252-15-9) + aniline (62-53-3) → 3-(4-methoxyphenyl)-1-phenyl-3-(N-phenylamino)propan-1-one (802-48-2)

Guidance literature:

With lithium nitrate/natural phosphate; In methanol; at 20 ℃; for 12h;

DOI:10.1080/10426500601160397

upstream raw materials:

4-methoxy-benzaldehyde

aniline

acetophenone

3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one

Downstream raw materials:

trans-4-methoxychalcone

Refernces

• 1、 Fan, Qi,Guo, Rui,Li, Ningbo,Ma, Rong,Qiao, Jie,Xu, Li,Xu, Shitang,Xu, Xinhua,Yun, Kemin. "Air-stable Organoantimony (III) Perfluoroalkyl(aryl)sulfonate complexes as highly efficient, selective, and recyclable catalysts for C–C and C–N bond-forming reactions". . . Retrieved 2021/07/08.
• 2、 Kaur, Bhupinder,Kumar, Harish. "Ultrasound-Promoted One-Pot Three-Component Synthesis of β–Amino Carbonyl Compounds Using Manganese Perchlorate". . p. 474 - 477. Retrieved 2020/10/02.