N-(2,2-Diphenylethyl)-N-methylamine

Base Information

• Chemical Name: N-(2,2-Diphenylethyl)-N-methylamine
• CAS No.: 80376-82-5
• Molecular Formula: C15H17N
• Molecular Weight: 211.307
• Hs Code.: 2921499090
• ChEMBL ID: CHEMBL10961
• DSSTox Substance ID: DTXSID30512828
• Nikkaji Number: J1.668.133D
• Wikidata: Q82372242
• Mol file: 80376-82-5.mol

Synonyms:N-(2,2-Diphenylethyl)-N-methylamine;80376-82-5;N-methyl-2,2-diphenylethanamine;N-Methyl-2,2-diphenylethan-1-amine;(2,2-Diphenyl-ethyl)-methyl-amine;(2,2-diphenylethyl)methylamine;N-methyldiphenylethylamine;CHEMBL10961;SCHEMBL1908636;BDBM35930;DTXSID30512828;WXSURELOKDGQNF-UHFFFAOYSA-N;MFCD14666467;AKOS009023921;AS-5980;(2,2-DIPHENYLETHYL)(METHYL)AMINE;CS-0301448;EN300-1862053

Chemical Property of N-(2,2-Diphenylethyl)-N-methylamine

Chemical Property:

• PSA: 12.03000
• LogP: 3.42880
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 211.136099547
• Heavy Atom Count: 16
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

(2,2-Diphenyl-ethyl)-methyl-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCC(C1=CC=CC=C1)C2=CC=CC=C2

Technology Process of N-(2,2-Diphenylethyl)-N-methylamine

There total 7 articles about N-(2,2-Diphenylethyl)-N-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-(methylamino)-1-phenylethanol (68579-60-2,6589-55-5) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → N-(2,2-diphenylethyl)-N-methylamine (80376-82-5)

Guidance literature:

With trifluorormethanesulfonic acid;

DOI:10.1021/ol016408y

Reference yield:

N-tert-Butyl-N'-(2,2-diphenyl-ethyl)-N'-methyl-methanediamine (80376-76-7) → N-(2,2-diphenylethyl)-N-methylamine (80376-82-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 2h; Yield given; Ambient temperature;

DOI:10.1021/ja00367a052

Reference yield:

N'-tert-Butyl-N-(2,2-diphenyl-vinyl)-N-methyl-formamidine (80376-68-7) → N-(2,2-diphenylethyl)-N-methylamine (80376-82-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium borohydride, 10percent HCl / aq. ethanol / 1 h / 0 °C / pH ca.6

2: 10percent HCl / tetrahydrofuran / 2 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; In tetrahydrofuran; ethanol;

DOI:10.1021/ja00367a052

upstream raw materials:

2,2-Diphenylethylamine

N-tert-Butyl-N'-(2,2-diphenyl-ethyl)-N'-methyl-methanediamine

2-(methylamino)-1-phenylethanol

benzene

Downstream raw materials:

2-benzoyl-N-{[(2,2-diphenyl-ethyl)-methyl-carbamoyl]-phenylmethyl}-N-[2-(1H-imidazol-4-yl)-ethyl]-benzamide

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2,2-diphenylethyl)-N-methylbutanamide

N,N'-Diallyl-6-{4-[(2,2-diphenyl-ethyl)-methyl-amino]-piperidin-1-yl}-[1,3,5]triazine-2,4-diamine

N,N-dimethyl-2,2-diphenyl-ethyl-1-amine

Refernces

• 1、 Klumpp,Aguirre,Sanchez Jr.,de Leon. "Reactions of amino alcohols in superacid: the direct observation of dicationic intermediates and their application in synthesis.". . p. 2781 - 2784. Retrieved 2007/10/03.
• 2、 -. "Urea, thiourea and guanidine compounds and their use as anti-viral agents". . . Retrieved 2008/06/13.