N-(2,5-difluorophenyl)formamide

Base Information

• Chemical Name: N-(2,5-difluorophenyl)formamide
• CAS No.: 81183-56-4
• Molecular Formula: C7H5F2NO
• Molecular Weight: 157.12
• Hs Code.: 2924297099
• DSSTox Substance ID: DTXSID00510250
• Wikidata: Q82368420
• Mol file: 81183-56-4.mol

Synonyms:N-(2,5-difluorophenyl)formamide;81183-56-4;N-(2,5-Difluoro-phenyl)-formamide;SCHEMBL1759061;DTXSID00510250;FOMMCVBZFYSEFW-UHFFFAOYSA-N;AKOS014324242;G10277

Chemical Property of N-(2,5-difluorophenyl)formamide

Chemical Property:

• PSA: 32.59000
• LogP: 2.18260
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 157.03392011
• Heavy Atom Count: 11
• Complexity: 142

Purity/Quality:

N-(2,5-Difluoro-phenyl)-formamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1F)NC=O)F

Technology Process of N-(2,5-difluorophenyl)formamide

There total 2 articles about N-(2,5-difluorophenyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2,5-difluoroaniline (367-30-6) + hexanal (66-25-1) → N-(2,5-difluorophenyl)formamide (81183-56-4)

Guidance literature:

With oxygen; manganese(III) triacetate dihydrate; In toluene; at 90 ℃; for 12h; under 760.051 Torr;

DOI:10.1021/ol300781s

Reference yield:

2,5-difluoroaniline (367-30-6) → N-(2,5-difluorophenyl)formamide (81183-56-4)

Guidance literature:

With formic acid; In hexane; benzene;

upstream raw materials:

2,5-difluoroaniline

hexanal

Refernces

• 1、 -. "N-Cyclopyopyl-N-(fluorophenyl)-N-acylureas and their herbidical use". . . Retrieved 2008/06/13.