4-METHYLBENZENE-1-CARBOXYLIC ANHYDRIDE

Base Information

• Chemical Name: 4-METHYLBENZENE-1-CARBOXYLIC ANHYDRIDE
• CAS No.: 13222-85-0
• Molecular Formula: C16H14 O3
• Molecular Weight: 254.285
• Hs Code.: 2916399090
• Mol file: 13222-85-0.mol

Synonyms:Benzoicacid, 4-methyl-, anhydride (9CI); p-Toluic anhydride (6CI,7CI,8CI);4-Methylbenzoic acid anhydride; 4-Methylbenzoic anhydride; p-Methylbenzoicanhydride

Chemical Property of 4-METHYLBENZENE-1-CARBOXYLIC ANHYDRIDE

Chemical Property:

• Vapor Pressure: 5.5E-07mmHg at 25°C
• Melting Point: 86-89℃
• Refractive Index: 1.5600 (estimate)
• Boiling Point: 411.6°Cat760mmHg
• Flash Point: 196°C
• PSA: 43.37000
• Density: 1.159g/cm³
• LogP: 3.30060
• Storage Temp.: Sealed in dry,Room Temperature
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

4-Methylbenzene-1-carboxylicanhydride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYLBENZENE-1-CARBOXYLIC ANHYDRIDE

There total 46 articles about 4-METHYLBENZENE-1-CARBOXYLIC ANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-methyl-benzoyl chloride (874-60-2) → p-methylbenzoic anhydride (13222-85-0)

Guidance literature:

With sodium hydrogencarbonate; In acetonitrile; at 45 ℃; for 5h; ultrasound;

DOI:10.1080/00397919708005024

Reference yield: 98.0%

p-Toluic acid (99-94-5) → p-methylbenzoic anhydride (13222-85-0)

Guidance literature:

With potassium carbonate; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield: 97.0%

potassium p-methyl benzoate (16518-25-5) + 4-methyl-benzoyl chloride (874-60-2) → p-methylbenzoic anhydride (13222-85-0)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; In chloroform; at 20 ℃; for 2h;

upstream raw materials:

para-chlorotoluene

p-Toluic acid

N-hydroxy-4-methylbenzamide

1,2-di(4-methylphenyl)-1,2-ethanedione

Downstream raw materials:

C₃₅H₃₂N₄O₈

4-Methylbenzoesaeure-difluorophosphorsaeure-anhydrid

4-Methylbenzoesaeure-dichlorophosphorsaeure-anhydrid

3-phenylpropionic acid 3-phenylpropyl ester

Refernces

• 1、 Ahmadzadeh, Zahra,Mokhtari, Javad,Rouhani, Morteza. "Cu-MOF: An efficient heterogeneous catalyst for the synthesis of symmetric anhydrides: Via the C-H bond activation of aldehydes". . p. 24203 - 24208. Retrieved 2018.
• 2、 Kaur, Avneet,Pathak, Dharam P.,Sharma, Vidushi,Wakode, Sharad. "Synthesis, molecular docking, and pharmacological evaluation of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives as selective COX-2 inhibitors and anti-inflammatory agents". . . Retrieved 2018.
• 3、 Dhimitruka, Ilirian,SantaLucia Jr., John. "Efficient Preparation of 2-Deoxy-3,5-di-O-p-toluoyl-α-D- ribofuranosyl Chloride". . p. 335 - 337. Retrieved 2004.
• 4、 Eidi, Esmaiel,Kassaee, Mohamad Z.,Nasresfahani, Zahra. "Efficient synthesis of symmetrical anhydrides by cross dehydrogenative coupling of aryl aldehydes over CuFe2O4 nanoparticles". . p. 461 - 468. Retrieved 2021.
• 5、 Saberi, Dariush,Shojaeyan, Fatemeh,Niknam, Khodabakhsh. "Oxidative self-coupling of aldehydes in the presence of CuCl2/TBHP system: Direct access to symmetrical anhydrides". . p. 566 - 569. Retrieved 2016.
• 6、 Liu, Yongmei,Liu, Ruzhang,Szostak, Michal. "Sc(OTf)3-catalyzed synthesis of anhydrides from twisted amides". . p. 1780 - 1785. Retrieved 2017.
• 7、 Pickel, Thomas C.,Akondi, Srirama Murthy,Liebeskind, Lanny S.. "Esterification by Redox Dehydration Using Diselenides as Catalytic Organooxidants". . p. 4954 - 4960. Retrieved 2019.
• 8、 Kawamura, Yasuhiko,Sato, Yoshinori,Horie, Tokunaru,Tsukayama, Masao. "Dehydration induced by intramolecular redox character of a stable allylidenetributylphosphorane". . p. 7893 - 7896. Retrieved 1997.
• 9、 -. "Preparation method of symmetric aromatic anhydride compound". Paragraph 0045-0046; 0057-0058. . Retrieved 2021/08/11.