Glycine, N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucyl]-

Base Information

• Chemical Name: Glycine, N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucyl]-
• CAS No.: 82007-05-4
• Molecular Formula: C23H26N2O5
• Molecular Weight: 410.46300
• Hs Code.: 2924297099
• DSSTox Substance ID: DTXSID20426526
• Nikkaji Number: J2.842.980K
• Wikidata: Q82239417
• Mol file: 82007-05-4.mol

Synonyms:Fmoc-Leu-Gly-OH;N-(9-fluorenylmethoxycarbonyl)-leucine-glycyl-OH

Chemical Property of Glycine, N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucyl]-

Chemical Property:

• Melting Point: 149-150 °C
• Boiling Point: 682.5±45.0 °C(Predicted)
• PKA: 3.39±0.10(Predicted)
• PSA: 111.71000
• Density: 1.237±0.06 g/cm3(Predicted)
• LogP: 4.18530
• Storage Temp.: -15°C
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 410.18417193
• Heavy Atom Count: 30
• Complexity: 601

Purity/Quality:

98.5% ^*data from raw suppliers

Fmoc-L-Leu-Gly-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NCC(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
• Isomeric SMILES: CC(C)C[C@@H](C(=O)NCC(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Technology Process of Glycine, N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucyl]-

There total 5 articles about Glycine, N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

H-Gly-(2-Cl)-Trt-pol + Fmoc-Leu-COSH (1359870-26-0) → (Fmoc)-Leu-Gly-OH (82007-05-4)

Guidance literature:

H-Gly-(2-Cl)-Trt-pol; Fmoc-Leu-COSH; With tert-butylisonitrile; benzotriazol-1-ol; In N,N-dimethyl-formamide; NovaSyn tentagel 4-carboxytrityl resin

With trifluoroacetic acid; In water; NovaSyn tentagel 4-carboxytrityl resin

DOI:10.1073/pnas.1310431110

Reference yield:

L-leucyl-glycine (686-50-0) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → (Fmoc)-Leu-Gly-OH (82007-05-4)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; Ambient temperature;

DOI:10.1021/jm00046a003

Reference yield:

Fmoc-Leu-Gly-OMe (1316293-41-0) → (Fmoc)-Leu-Gly-OH (82007-05-4)

Guidance literature:

With water; calcium chloride; sodium hydroxide; In isopropyl alcohol;

DOI:10.1002/rcm.5076

upstream raw materials:

L-leucyl-glycine

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Fmoc-Leu-Gly-OMe

Fmoc-Leu-OH

Refernces

• 1、 Ramesh,Raju,Srinivas,Sureshbabu,Vishwanatha,Hemantha. "Characterization of Nα-Fmoc-protected dipeptide isomers by electrospray ionization tandem mass spectrometry (ESI-MSn): Effect of protecting group on fragmentation of dipeptides". experimental part. p. 1949 - 1958. Retrieved 2012/05/20.