N-Fmoc-8-aminooctanoic acid

Base Information

• Chemical Name: N-Fmoc-8-aminooctanoic acid
• CAS No.: 3627-51-8
• Deprecated CAS: 13479-32-8,11042-58-3,511-14-8
• Molecular Formula: C₂₃H₂₇NO₄
• Molecular Weight: 381.472
• European Community (EC) Number: 848-538-2
• UNII: WQ3PS53E2U
• DSSTox Substance ID: DTXSID90189813
• Wikidata: Q83062026
• Mol file: 3627-51-8.mol

Synonyms:monascorubramine

Chemical Property of N-Fmoc-8-aminooctanoic acid

Chemical Property:

• XLogP3: 4.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 11
• Exact Mass: 381.19400834
• Heavy Atom Count: 28
• Complexity: 487

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCCCCCCC(=O)O

Technology Process of N-Fmoc-8-aminooctanoic acid

There total 4 articles about N-Fmoc-8-aminooctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

monascorubrin (13283-90-4) → monascorubramine (3627-51-8,511-14-8)

Guidance literature:

With ammonium sulfate; In ethanol; at 30 ℃; for 72h;

DOI:10.1016/j.dyepig.2019.107965

Reference yield:

→ monascorubramine (3627-51-8,511-14-8)

Guidance literature:

With ammonia;

DOI:10.1016/S0040-4020(01)99285-3 DOI:10.1021/ja01532a068

Reference yield:

11b-methyl-5-pentyl-10-trans-propenyl-4,5,6a,7,11a,11b-hexahydro-1,6,9-trioxa-naphtho[1,2,3-cd]azulene-2,3-dione → 9a-methyl-3-octanoyl-6-trans-propenyl-7H,9aH-furo[3,2-g]isoquinoline-2,9-dione (3627-51-8,511-14-8)

Guidance literature:

With ammonium hydroxide; at 0 ℃; for 0.0833333h;

DOI:10.1016/S0040-4020(01)99285-3

upstream raw materials:

monascorubrin

Downstream raw materials:

(9aR)-9ξ-hydroxy-9a-methyl-3-octanoyl-6-trans-propenyl-9,9a-dihydro-7H-furo[3,2-g]isoquinolin-2-one

3-bromo-3-(2-bromo-octanoyl)-6-(1,2-dibromo-propyl)-9-hydroxy-9a-methyl-9,9a-dihydro-3H-furo[3,2-g]isoquinolin-2-one

9-hydroxy-9a-methyl-3-octanoyl-6-trans-propenyl-9,9a-dihydro-7H-furo[3,2-g]isoquinolin-2-one

3-bromo-3-(2-bromo-octanoyl)-6-(1,2-dibromo-propyl)-9a-methyl-3H,9aH-furo[3,2-g]isoquinoline-2,9-dione

Refernces