potassiuM (S)-oxirane-2-carboxylate

Base Information

• Chemical Name: potassiuM (S)-oxirane-2-carboxylate
• CAS No.: 82079-45-6
• Molecular Formula: C3H4O3.K
• Molecular Weight: 126.153
• Mol file: 82079-45-6.mol

Synonyms:potassium (2S)-2,3-epoxypropionate;potassium (S)-oxirane-2-carboxylate;S-oxiranecarboxylic acid potassium salt;potassium (2S)-oxirane-2-carboxylate;potassium de l'acide (S)-(-)-epoxy-2,3 propionique;L-potassium glycidate;

Chemical Property of potassiuM (S)-oxirane-2-carboxylate

Chemical Property:

• PSA: 52.66000
• LogP: -1.86490

Purity/Quality:

NLT 98% ^*data from raw suppliers

Potassium (S)-oxirane-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of potassiuM (S)-oxirane-2-carboxylate

There total 8 articles about potassiuM (S)-oxirane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl (2S)-glycidate (4538-50-5,85485-00-3,111058-32-3,118712-39-3) → potassium de l'acide (S)-(-)-epoxy-2,3 propionique (82079-45-6)

Guidance literature:

With potassium hydroxide; In ethanol; at 60 ℃; for 1h;

DOI:10.1016/j.tetlet.2019.151103

Reference yield: 80.0%

acide (R)-(+)-bromo-2 hydroxy-3 propionique (110994-91-7) → potassium de l'acide (S)-(-)-epoxy-2,3 propionique (82079-45-6)

Guidance literature:

With potassium hydroxide; In methanol; at 5 ℃; for 15h;

DOI:10.1016/0223-5234(92)90180-9

Reference yield: 78.0%

(R)-3-Chloro-2-hydroxypropanoic acid (61505-41-7) → potassium de l'acide (S)-(-)-epoxy-2,3 propionique (82079-45-6)

Guidance literature:

With potassium hydroxide; In methanol; 1) room temperature, 1 h; 2) 5 deg C, overnight;

DOI:10.1021/ja00380a021

upstream raw materials:

(R)-3-Chloro-2-hydroxypropanoic acid

acide (R)-(+)-bromo-2 hydroxy-3 propionique

serin

acide (S)-(-)-bromo-2 hydroxy-3 propionique

Downstream raw materials:

ethyl (S)-(-)-2,3-epoxypropanoate

methyl (2S)-glycidate

(R)-2-Hydroxy-3-(phenylthio)propanoic acid

(S)-(-)-glycidate de benzyle

Refernces

• 1、 -. "Pyrazolopyrimidine derivative, preparation method, pharmaceutical composition and application". Paragraph 0307; 0308; 0309. . Retrieved 2017/07/19.
• 2、 Eichenauer, Nils C.,Tschersich, Roxanne,Pietruszka, J?rg. "Total Synthesis of Solandelactone i". . p. 2782 - 2790. Retrieved 2015/12/09.