O-Methylpallidine【Corydalis】

Base Information

• Chemical Name: O-Methylpallidine【Corydalis】
• CAS No.: 27510-33-4
• Molecular Formula: C₂₀H₂₃NO₄
• Molecular Weight: 341.407
• Mol file: 27510-33-4.mol

Synonyms:9a,13a-Morphinan-7-one,5,6,8,14-tetradehydro-2,3,6-trimethoxy-17-methyl- (8CI); (+)-O-Methylpallidine;(-)-Sebiferine; (9S)-Sebiferine; Fissistigine C; O-Methyl-(+)-flavinantine;O-Methylpallidine

Chemical Property of O-Methylpallidine【Corydalis】

Chemical Property:

• PSA: 48.00000
• LogP: 2.17910

Purity/Quality:

>=95% ^*data from raw suppliers

O-Methylpallidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: This alkaloid has also been recently isolated from Rhigiocarya racemifera where it occurs mainly in the roots.

Technology Process of O-Methylpallidine【Corydalis】

There total 9 articles about O-Methylpallidine【Corydalis】 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (9S)-(-)-norsebiferine (169437-91-6) → O-methylpallidine (27510-33-4,121822-42-2,20948-08-7)

Guidance literature:

With formic acid; for 10h; Heating;

DOI:10.1016/0957-4166(95)00213-9

Reference yield:

(S)-pallidine hydrochloride + dimethyl sulfate (77-78-1) → O-methylpallidine (27510-33-4,121822-42-2,20948-08-7)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 35 ℃; for 4h;

DOI:10.1039/P19810000578

Reference yield:

(9S)-(+)-N-trifluoroacetylnorsebiferine (61659-88-9) → O-methylpallidine (27510-33-4,121822-42-2,20948-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / aq.K₂CO₃ / methanol / 5 h / Heating

2: 53 percent / 85percent HCO₂H / 10 h / Heating

With formic acid; potassium carbonate; In methanol;

DOI:10.1016/0957-4166(95)00213-9

upstream raw materials:

C₂₀H₂₄BrNO₄

dimethyl sulfate

formaldehyd

(9S)-(-)-norsebiferine

Refernces

• 1、 Gawley, Robert E.,Smith, Gregory A.. "SYNTHESIS OF R-LAUDANOSINE AND 9-R-O-METHYLFLAVINANTINE BY ASYMMETRIC ALKYLATION". . p. 301 - 302. Retrieved 2007/10/02.