1-(2-methoxyphenyl)-N-[4-[4-(4-methylphenyl)piperazin-1-yl]phenyl]meth animine

Base Information

• Chemical Name: 1-(2-methoxyphenyl)-N-[4-[4-(4-methylphenyl)piperazin-1-yl]phenyl]meth animine
• CAS No.: 78932-99-7
• Molecular Formula: C25H27 N3 O
• Molecular Weight: 0
• Mol file: 78932-99-7.mol

Synonyms:1-(2-methoxyphenyl)-N-[4-[4-(4-methylphenyl)piperazin-1-yl]phenyl]meth animine

Chemical Property of 1-(2-methoxyphenyl)-N-[4-[4-(4-methylphenyl)piperazin-1-yl]phenyl]meth animine

Chemical Property:

• Vapor Pressure: 7.83E-14mmHg at 25°C
• Boiling Point: 588.6°C at 760 mmHg
• Flash Point: 309.8°C
• PSA: 28.07000
• Density: 1.09g/cm³
• LogP: 5.21080

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-methoxyphenyl)-N-[4-[4-(4-methylphenyl)piperazin-1-yl]phenyl]meth animine

There total 4 articles about 1-(2-methoxyphenyl)-N-[4-[4-(4-methylphenyl)piperazin-1-yl]phenyl]meth animine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ortho-anisaldehyde (135-02-4) + 4-(4-p-tolyl-piperazin-1-yl)-phenylamine (68944-99-0) → [1-(2-Methoxy-phenyl)-meth-(E)-ylidene]-[4-(4-p-tolyl-piperazin-1-yl)-phenyl]-amine (78932-99-7)

Guidance literature:

In benzene; for 8h; Heating;

Reference yield:

(4-methylphenyl)piperazine (39593-08-3) → [1-(2-Methoxy-phenyl)-meth-(E)-ylidene]-[4-(4-p-tolyl-piperazin-1-yl)-phenyl]-amine (78932-99-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / 48 h / 120 - 140 °C

2: 85 percent / hydrazin hydrate (98 percent) / Raney nickel / dimethylformamide / 10 h / Heating

3: 65 percent / benzene / 8 h / Heating

With hydrazine hydrate; nickel; In N,N-dimethyl-formamide; benzene;

Reference yield:

4-chlorobenzonitrile (100-00-5) → [1-(2-Methoxy-phenyl)-meth-(E)-ylidene]-[4-(4-p-tolyl-piperazin-1-yl)-phenyl]-amine (78932-99-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / 48 h / 120 - 140 °C

2: 85 percent / hydrazin hydrate (98 percent) / Raney nickel / dimethylformamide / 10 h / Heating

3: 65 percent / benzene / 8 h / Heating

With hydrazine hydrate; nickel; In N,N-dimethyl-formamide; benzene;

upstream raw materials:

ortho-anisaldehyde

4-(4-p-tolyl-piperazin-1-yl)-phenylamine

(4-methylphenyl)piperazine

4-chlorobenzonitrile

Downstream raw materials:

(2-Methoxy-benzyl)-[4-(4-p-tolyl-piperazin-1-yl)-phenyl]-amine

Refernces