1-Eicosanamine

Base Information

• Chemical Name: 1-Eicosanamine
• CAS No.: 10525-37-8
• Molecular Formula: C20H43 N
• Molecular Weight: 297.568
• Hs Code.: 2921199090
• UNII: 594M3CY45Q
• DSSTox Substance ID: DTXSID9065108
• Nikkaji Number: J414.444I
• Wikidata: Q27261652
• ChEMBL ID: CHEMBL110012
• Mol file: 10525-37-8.mol

Synonyms:icosan-1-amine;1-Eicosanamine;10525-37-8;Eicosylamine;Icosylamine;1-icosanamine;UNII-594M3CY45Q;CHEMBL110012;594M3CY45Q;arachidylamine;eicosanylamine;arachidyl amine;n-eicosylamine;1-AMINOEICOSANE;SCHEMBL75275;LCZC1198;DTXSID9065108;BDBM50147567;MFCD08272121;AKOS016004164;A10999;Q27261652

Chemical Property of 1-Eicosanamine

Chemical Property:

• Vapor Pressure: 8.96E-06mmHg at 25°C
• Melting Point: 57.8℃
• Refractive Index: 1.4385 (589.3 nm 60℃)
• Boiling Point: 373.4°Cat760mmHg
• PKA: 10.67±0.10(Predicted)
• Flash Point: 168.7°C
• PSA: 26.02000
• Density: 0.821g/cm³
• LogP: 7.68710
• XLogP3: 9.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 18
• Exact Mass: 297.339550376
• Heavy Atom Count: 21
• Complexity: 167

Purity/Quality:

98%,99%, ^*data from raw suppliers

Icosan-1-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCCCCCCCCCN

Technology Process of 1-Eicosanamine

There total 9 articles about 1-Eicosanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-eicosylphthalimide → 1-aminoeicosane (10525-37-8)

Guidance literature:

With methylamine; In methanol; at 80 ℃; for 16h; Schlenk technique;

DOI:10.1002/chem.201500707

Reference yield: 75.0%

1-azidoicosane (935676-78-1) → 1-aminoeicosane (10525-37-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In hexane; at 20 ℃; for 3h; under 3206.4 Torr;

DOI:10.1021/jm061240d

Reference yield:

1-Bromoeicosane (4276-49-7) → 1-aminoeicosane (10525-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / NaN₃; hexadecyltrimethylammonium bromide / H₂O / 72 h / 80 - 90 °C

2: 75 percent / H₂ / Pd/C / hexane / 3 h / 20 °C / 3206.4 Torr

With sodium azide; hydrogen; cetyltrimethylammonim bromide; palladium on activated charcoal; In hexane; water;

DOI:10.1021/jm061240d

upstream raw materials:

Eicosanylamide

1-azidoicosane

n-eicosanol

1-Bromoeicosane

Downstream raw materials:

Eicosanylamide

N-icosyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetamide

Refernces

• 1、 Sugandhi, Eko W.,Macri, Richard V.,Williams, André A.,Kite, Brett L.,Slebodnick, Carla,Falkinham III, Joseph O.,Esker, Alan R.,Gandour, Richard D.. "Synthesis, critical micelle concentrations, and antimycobacterial properties of homologous, dendritic amphiphiles. Probing intrinsic activity and the "cutoff" effect". . p. 1645 - 1650. Retrieved 2007.
• 2、 Nagase,Kuwahara,Tominaga,Sugawara. "Nematicidal activity of N-substituted and N,N-disubstituted alkylamines against the pine wood nematode, Bursaphelenchus xylophilus". . p. 53 - 58. Retrieved 2007/10/02.