5-Benzofurancarboxaldehyde, 4-hydroxy-

Base Information

• Chemical Name: 5-Benzofurancarboxaldehyde, 4-hydroxy-
• CAS No.: 59292-71-6
• Molecular Formula: C9H6 O3
• Molecular Weight: 162.145
• Mol file: 59292-71-6.mol

Synonyms:NSC 278074

Chemical Property of 5-Benzofurancarboxaldehyde, 4-hydroxy-

Chemical Property:

• Vapor Pressure: 0.984mmHg at 25°C
• Melting Point: 60 °C(Solv: water (7732-18-5))
• Boiling Point: 172.7°C at 760 mmHg
• PKA: 7.53±0.50(Predicted)
• Flash Point: 58.3°C
• PSA: 50.44000
• Density: 1.392g/cm³
• LogP: 1.95090

Purity/Quality:

99% ^*data from raw suppliers

4-hydroxy-5-Benzofurancarboxaldehyde 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Benzofurancarboxaldehyde, 4-hydroxy-

There total 8 articles about 5-Benzofurancarboxaldehyde, 4-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-hydroxymethylene-4,5,6,7-tetrahydrobenzofuran-4-one enol form (162794-47-0) → 4-hydroxybenzofuran-5-carboxaldehyde (59292-71-6)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; for 3h; Heating;

DOI:10.1016/0040-4020(95)00070-O

Reference yield: 50.0%

4-(2,2-dimethoxyethoxy)-2-hydroxybenzaldehyde → 6-hydroxy-5-benzofurancarboxaldehyde (20073-22-7) + 4-hydroxybenzofuran-5-carboxaldehyde (59292-71-6)

Guidance literature:

With Amberlyst-15 resin; In toluene; for 24h; Reflux; Dean-Stark;

DOI:10.1016/j.tetlet.2015.01.114

Reference yield:

(+/-)-3,3-dimethyloxirane-2-carboxaldehyde (5369-62-0) + 2,4-Dihydroxybenzaldehyde (95-01-2) → 4-hydroxybenzofuran-5-carboxaldehyde (59292-71-6)

Guidance literature:

(+/-)-3,3-dimethyloxirane-2-carboxaldehyde; 2,4-Dihydroxybenzaldehyde; With potassium hydroxide; calcium chloride; In methanol; at 25 ℃; for 24h;

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1021/jo047974k

upstream raw materials:

4-hydroxybenzofuran

5-hydroxymethylene-4,5,6,7-tetrahydrobenzofuran-4-one enol form

(+/-)-3,3-dimethyloxirane-2-carboxaldehyde

2,4-Dihydroxybenzaldehyde

Refernces

• 1、 Sairam, Mudulkar,Saidachary, Gannerla,Raju, Bhimapaka China. "Condensation of salicylaldehydes with ethyl 4,4,4-trichloro-3-oxobutanoate: A facile approach for the synthesis of substituted 2H-chromene-3-carboxylates". . p. 1338 - 1343. Retrieved 2015/03/04.
• 2、 Lee. "A concise new synthesis of angular furanocoumarins: Angelicin, oroselone and oroselol". . p. 3087 - 3094. Retrieved 2007/10/02.