Technology Process of 1,4-Dioxaspiro[4.14]nonadecane-2,3-dicarboxamide,
7-methyl-N,N'-bis(phenylmethyl)-, (2R,3R,7R)-
There total 4 articles about 1,4-Dioxaspiro[4.14]nonadecane-2,3-dicarboxamide,
7-methyl-N,N'-bis(phenylmethyl)-, (2R,3R,7R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
scandium tris(trifluoromethanesulfonate); trimethyl orthoformate;
In
acetonitrile;
for 2h;
Heating;
DOI:10.1016/j.tetlet.2005.03.119
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hexamethyldisilazide / tetrahydrofuran / 15 h / 20 °C
1.2: sodium hydroxide / methanol; H2O / 3 h / Heating
1.3: sulfuric acid / methanol; H2O / 2 h / Heating
2.1: trimethyl orthoformate; scandium(III) trifluoromethanesulfonate / acetonitrile / 5 h / Heating
With
lithium hexamethyldisilazane; scandium tris(trifluoromethanesulfonate); trimethyl orthoformate;
In
tetrahydrofuran; acetonitrile;
1.1: Dieckmann cyclization;
DOI:10.1016/j.tetasy.2005.08.042
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: p-toluenesulfonic acid monohydrate / toluene / 6 h / Heating
2.1: lithium hexamethyldisilazide / tetrahydrofuran / 15 h / 20 °C
2.2: sodium hydroxide / methanol; H2O / 3 h / Heating
2.3: sulfuric acid / methanol; H2O / 2 h / Heating
3.1: trimethyl orthoformate; scandium(III) trifluoromethanesulfonate / acetonitrile / 5 h / Heating
With
toluene-4-sulfonic acid; lithium hexamethyldisilazane; scandium tris(trifluoromethanesulfonate); trimethyl orthoformate;
In
tetrahydrofuran; toluene; acetonitrile;
2.1: Dieckmann cyclization;
DOI:10.1016/j.tetasy.2005.08.042